Evidence map›Paper›PMID 28268062›Full record

ArticleTrends in immunology2017

Regulating Damage from Sterile Inflammation: A Tale of Two Tolerances.

Shin-Rong Wu, Pavan Reddy

Abstract read
In one paragraph

Article in Trends in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Shin-Rong WuGraduate Program in Immunology, University of Michigan Medical School, Ann Arbor, MI, USA; Department of Internal Medicine, Michigan Medicine, Ann Arbor, MI, USA.
Pavan ReddyDepartment of Internal Medicine, Michigan Medicine, Ann Arbor, MI, USA. Electronic address: reddypr@umich.edu.

Funding

MICHIGAN MEDICAL SCIENTIST TRAINING PROGRAMT32GM007863 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI COLLINS, KATHLEEN L. · 1985 to 2024
$38.3M
Targeting antigen presentation to enhance GVL responses after Bone Marrow TransplR01HL090775 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI REDDY, PAVAN · 2008 to 2016
$3.4M
Cellular and molecular mechanisms of target tissue resistance for mitigating GVHD severityR01CA203542 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI REDDY, PAVAN · 2016 to 2020
$2.4M
Development of novel strategy for treatment of steroid refractory GVHDR01HL128046 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI REDDY, PAVAN · 2015 to 2019
$2.1M
Role of noncoding RNA in Regulating GVHDR01CA173878 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI REDDY, PAVAN · 2013 to 2017
$1.6M
Development of a Novel Strategy to Prevent Experimental GVHDR01CA143379 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI REDDY, PAVAN · 2010 to 2014
$739k
NCI NIH HHS R01 CA143379NCI NIH HHS R01 CA173878NCI NIH HHS R01 CA203542NHLBI NIH HHS R01 HL090775NHLBI NIH HHS R01 HL128046NIGMS NIH HHS T32 GM007863
6 · The paper itself

Abstract

The severity of immunopathology from non-infectious inflammation is mainly understood and is managed by targeting immune cells. However, the role of target tissues in determining damage severity has been largely overlooked. Here, we discuss the concept of 'tissue tolerance' for tissue-intrinsic programs that ameliorate organ damage in the setting of sterile immunopathology.

Indexed as

AutoimmunityImmune ToleranceAnimalsCellular MicroenvironmentHumansImmunologic Deficiency SyndromesImmunotherapyInflammationModels, ImmunologicalOrgan Specificity

Identifiers

PMID28268062
PMCPMC5384109

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.