ArticlePloS one2017
mRNA N6-methyladenosine methylation of postnatal liver development in pig.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 61 citations in OpenAlex.
- Transcriptome-Wide Analysis of N6-Methyladenosine Modification in the Liver of Geese at Different Growth Stages.Animals : an open access journal from MDPI · 2026Article
- Transcriptome-Wide Identification and Analysis Reveals mVeterinary sciences · 2025Article
- N6-methyladenosine improves porcine longissimus dorsi muscle quality by regulating myofiber differentiation.BMC genomics · 2025Article
- Immune stress impairs broiler performance by affecting hypothalamic methylation modification and intestinal 5-HT synthesis.Poultry science · 2025Article
- Transcriptome-wide m6A landscape across diverse porcine tissues revealed by nanopore direct RNA sequencing.Frontiers in genetics · 2025Article
- Transcriptome-wide methylated RNA immunoprecipitation sequencing profiling reveals m6A modification involved in response to heat stress in Apostichopus japonicus.BMC genomics · 2024Article
- Comprehensive analysis of lncRNAs modified by m6A methylation in sheep skin.Animal bioscience · 2024Article
- Article
- DNA methylation regulates RNA mCell proliferation · 2024Article
- mEpigenetics · 2023Article
- Changes in m6A in Steatotic Liver Disease.Genes · 2023Review
- Alphaherpesvirus-mediated remodeling of the cellular transcriptome results in depletion of m6A-containing transcripts.iScience · 2023Article
- Pseudorabies virus exploits NFrontiers in microbiology · 2023Article
- Comprehensive Analysis Revealed the Potential Roles of NInternational journal of molecular sciences · 2022Article
- RNA m6A modification in liver biology and its implication in hepatic diseases and carcinogenesis.American journal of physiology. Cell physiology · 2022Review
- Emerging roles of the RNA modifications N6-methyladenosine and adenosine-to-inosine in cardiovascular diseases.Molecular therapy. Nucleic acids · 2022Review
- Transcriptome-wide NaBIOTECH · 2022Article
- Mettl3-mediated mRNA mNature communications · 2022Article
- Liver-specific Mettl3 ablation delays liver regeneration in mice.Genes & diseases · 2022Article
- The Role of NCells · 2022Review
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
N6-methyladenosine (m6A) is a ubiquitous reversible epigenetic RNA modification that plays an important role in the regulation of post-transcriptional protein coding gene expression. Liver is a vital organ and plays a major role in metabolism with numerous functions. Information concerning the dynamic patterns of mRNA m6A methylation during postnatal development of liver has been long overdue and elucidation of this information will benefit for further deciphering a multitude of functional outcomes of mRNA m6A methylation. Here, we profile transcriptome-wide m6A in porcine liver at three developmental stages: newborn (0 day), suckling (21 days) and adult (2 years). About 33% of transcribed genes were modified by m6A, with 1.33 to 1.42 m6A peaks per modified gene. m6A was distributed predominantly around stop codons. The consensus motif sequence RRm6ACH was observed in 78.90% of m6A peaks. A negative correlation (average Pearson's r = -0.45, P < 10-16) was found between levels of m6A methylation and gene expression. Functional enrichment analysis of genes consistently modified by m6A methylation at all three stages showed genes relevant to important functions, including regulation of growth and development, regulation of metabolic processes and protein catabolic processes. Genes with higher m6A methylation and lower expression levels at any particular stage were associated with the biological processes required for or unique to that stage. We suggest that differential m6A methylation may be important for the regulation of nutrient metabolism in porcine liver.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.