ArticlePloS one2017
Low cord-serum 25-hydroxyvitamin D levels are associated with poor lung function performance and increased respiratory infection in infancy.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Determinants and Measurement of Neonatal Vitamin D: Overestimation of 25(OH)D in Cord Blood Using CLIA Assay Technology.The Journal of clinical endocrinology and metabolism · 2020Trial
- Association between serum 25-hydroxyvitamin D concentrations and respiratory infections in US preschool children: a population-based study.European journal of pediatrics · 2025Article
- The effects of prenatal vitamin D supplementation on respiratory and allergy-related outcomes in children: A systematic review and meta-analysis of randomized controlled trials.The World Allergy Organization journal · 2025Review
- The vascular phenotype of BPD: new basic science insights-new precision medicine approaches.Pediatric research · 2024Review
- Association of Maternal Gestational Vitamin D Supplementation with Respiratory Health of Young Children.Nutrients · 2023Article
- Vitamin D: A Potential Mitigation Tool for the Endemic Stage of the COVID-19 Pandemic?Frontiers in public health · 2022Review
- Article
- Review
- Prevalence and Correlates of Vitamin D Deficiency among Young South African Infants: A Birth Cohort Study.Nutrients · 2021Article
- Low Vitamin D Levels at Birth and Early Respiratory Outcome in Infants With Gestational Age Less Than 29 Weeks.Frontiers in pediatrics · 2021Article
- Determinants of vitamin D status in Kenyan calves.Scientific reports · 2020Article
- The Role of Micronutrients in Support of the Immune Response against Viral Infections.Nutrients · 2020Review
- Association of vitamin D supplementation with respiratory tract infection in infants.Maternal & child nutrition · 2020Article
- Association Between Vitamin D and Novel SARS-CoV-2 Respiratory Dysfunction - A Scoping Review of Current Evidence and Its Implication for COVID-19 Pandemic.Frontiers in physiology · 2020Article
- The association between vitamin D status and infectious diseases of the respiratory system in infancy and childhood.Hormones (Athens, Greece) · 2019Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPerinatal vitamin D deficiency is associated with a higher risk of wheezing in childhood. However, the relationship between vitamin D levels and lung function in infancy has not been investigated. The aim of this study was to investigate the impact of perinatal vitamin D levels on respiratory function and disease outcome in infancy. MATERIALS AND
methodsFull-term infants without any chronic diseases or major anomalies were enrolled in the Prediction of Allergies in Taiwanese Children cohort study. Maternal and cord blood were collected for determining the 25(OH)D level. Questionnaires were recorded at birth and 6 months of age. Infant lung function, including tidal breathing analysis, respiratory mechanics, and forced tidal expiration, was tested at 6 months of age.
resultsA total of 122 mother-infant pairs were enrolled in this study, and 71 infants underwent lung function testing at 6 months of age. 25(OH)D levels in maternal and cord serum were highly correlated (r2 = 0.457, p < 0.0001). Infants with lower cord serum 25(OH)D levels (< 13.7 ng/ml) had higher resistance of respiratory system (p < 0.01) and a higher risk of a respiratory tract infection before the age of 6 months (p < 0.01).
conclusionAlthough a high correlation was found between maternal and cord vitamin D levels, the effect on respiratory outcome was different. Our study is the first to show that low cord 25(OH)D levels significantly relationship with poorer lung function performance and higher likelihood of a respiratory tract infection before 6 months of age.
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