ArticlePloS one2017
Evaluation of allograft contamination and decontamination at the Treviso Tissue Bank Foundation: A retrospective study of 11,129 tissues.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 32 citations in OpenAlex.
- 20-year analysis of protocol-driven quality improvement in cardiac homograft banking.Cell and tissue banking · 2026Article
- Cryopreservation Maintains Structural Integrity and Biomechanical Properties of Human Rectus Fascia for up to 1 mo.Transplantation direct · 2026Article
- Effects of Hydrodynamic Ozonated Water Processing on the Thermal Stability and Structural Integrity of the Human Amniotic Membrane.Journal of functional biomaterials · 2026Article
- Enhancing cadaver preparation protocol to reduce bacterial contamination in musculoskeletal allografts: a comparative study of battlefield fatalities and general population donors.Cell and tissue banking · 2026Article
- Microbiological risk assessment during the procurement and processing of cells, tissues and breast milk using the MiRCA tool.Scientific reports · 2025Article
- Bioburden of postmortem bone tissues with a procurement time exceeding 36 h.Cell and tissue banking · 2025Article
- A local, non-commercial tissue bank connected to an organ donor program can produce musculoskeletal allografts of uniform quality at very low costs - ten years' experience.Cell and tissue banking · 2024Article
- Does microbiological contamination of homografts prior to decontamination affect the outcome after right ventricular outflow tract reconstruction?Interactive cardiovascular and thoracic surgery · 2021Article
- Impact of valve fenestrations and structural changes in homografts on the long-term outcome in the recipient.Cell and tissue banking · 2021Article
- The use of allograft tendons in primary ACL reconstruction.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2019Review
- Experimental procedures for decontamination and microbiological testing in cardiovascular tissue banks.Experimental biology and medicine (Maywood, N.J.) · 2018Review
- Evaluation of allograft decontamination with two different antibiotic cocktails at the Treviso Tissue Bank Foundation.PloS one · 2018Article
- Analysis of potential factors affecting allografts contamination at retrieval.Cell and tissue banking · 2017Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microbiological contamination of retrieved tissues has become a very important topic and a critical aspect in the safety of allografts. We have analysed contamination in 11,129 tissues with a longitudinal contamination profile for each individual tissue. More specifically, 10,035 musculoskeletal tissues and 1,094 cardiovascular tissues were retrieved from a total of 763 multi-tissue donors, of whom 105 were heart-beating donors as well as organ donors, while the remaining 658 were non-heart beating donors and tissue donors only. All tissues were decontaminated twice, the first time immediately after retrieval and the second time after processing. Each tissue was submitted to microbiological culture three times, i.e., upon retrieval (Time 1), after the first decontamination (Time 2) and after the second decontamination (Time 3). The contamination rate for musculoskeletal tissues was 52%, 16.2% and 0.5% at Time 1, 2 and 3, respectively. The contamination rate for cardiovascular tissues was 84%, 42% and 6%. More than one strain was simultaneously present in 10.8% of musculoskeletal tissues and 44.6% of cardiovascular tissues. Out of 8,560 non-heart-beating donor musculoskeletal tissues, 4,689 (54.8%), 1,383 (16.2%) and 42 (0.5%) were contaminated at Time 1, Time 2 and Time 3, respectively. Out of 1,475 heart-beating donor musculoskeletal tissues, 522 (35.4%) 113 (7.7%) and 2 (0.1%) tissues were found to be contaminated at Time 1, 2 and 3, respectively. Out of 984 non-heart beating donor cardiovascular tissues, 869 (88.3%), 449 (45.6%) and 69 (7%) proved positive at Time 1, 2 and 3 respectively, while 50 (45.5%) and 10 (9.1%) heart-beating donor cardiovascular tissues were contaminated at Time 1 and 2. No tissue was contaminated at Time 3. Based on our methods, the two-step decontamination approach is mandatory in order to drastically reduce the number of tissues found to be positive at the end of the process.
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