Evidence map›Paper›PMID 28267676›Full record

ReviewPharmacological reviews2017

Contrasting Regulation of Catecholamine Neurotransmission in the Behaving Brain: Pharmacological Insights from an Electrochemical Perspective.

Megan E Fox, R Mark Wightman

Open access · bronzeAbstract readReview
In one paragraph

Review in Pharmacological reviews, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 31 citations in OpenAlex.

  1. Trial
  2. Review
  3. Adrenergic C1 neurons enhance anxiety via projections to PAG.bioRxiv : the preprint server for biology · 2024
    Article
  4. Article
  5. Where Is Dopamine and how do Immune Cells See it?: Dopamine-Mediated Immune Cell Function in Health and Disease.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2020
    Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Megan E FoxDepartment of Chemistry and Neuroscience Center, University of North Carolina, Chapel Hill, North Carolina.
R Mark WightmanDepartment of Chemistry and Neuroscience Center, University of North Carolina, Chapel Hill, North Carolina rmw@unc.edu.
University of North Carolina at Chapel Hill · US

Funding

DYNAMICS OF IN VIVO DOPAMINE RELEASER01DA010900 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WIGHTMAN, ROBERT MARK · 1997 to 2017
$5.1M
NIDA NIH HHS R01 DA010900
6 · The paper itself

Abstract

Catecholamine neurotransmission plays a key role in regulating a variety of behavioral and physiologic processes, and its dysregulation is implicated in both neurodegenerative and neuropsychiatric disorders. Over the last four decades, in vivo electrochemistry has enabled the discovery of contrasting catecholamine regulation in the brain. These rapid and spatially resolved measurements have been conducted in brain slices, and in anesthetized and freely behaving animals. In this review, we describe the methods enabling in vivo measurements of dopamine and norepinephrine, and subsequent findings regarding their release and regulation in intact animals. We thereafter discuss key studies in awake animals, demonstrating that these catecholamines are not only differentially regulated, but are released in opposition of each other during appetitive and aversive stimuli.

Indexed as

Behavior, AnimalAnimalsBrainCatecholaminesDopamineHumansMembrane PotentialsModels, AnimalNeuronal PlasticityNeuronsNeurotransmitter AgentsSubstance-Related DisordersCatecholaminesDopamineNeurotransmitter Agents

Identifiers

PMID28267676
PMCPMC7558309
OpenAlexW2556717556

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.