Evidence map›Paper›PMID 28267472›Full record

SynthesisAmerican heart journal2017

Intravascular ultrasound-guided vs angiography-guided drug-eluting stent implantation in complex coronary lesions: Meta-analysis of randomized trials.

Chirag Bavishi, Partha Sardar, Saurav Chatterjee, Abdur Rahman Khan, Arpit Shah, Sameer Ather, Pedro A Lemos, Pedro Moreno, Gregg W Stone

Abstract readComparative StudyMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in American heart journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 8 pooled it
11.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 8 syntheses or guidelines pooled it, 132 citations in OpenAlex.

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  11. Optimal Stent Expansion Indices for Predicting Outcomes in PCI of Calcified Coronary Lesions.Clinical research in cardiology : official journal of the German Cardiac Society · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Chirag BavishiMount Sinai St Luke's & Mount Sinai West Hospitals, New York, NY.
Partha SardarUniversity of Utah, Salt Lake City, UT.
Saurav ChatterjeeMount Sinai St Luke's & Mount Sinai West Hospitals, New York, NY.
Abdur Rahman KhanUniversity of Louisville, Louisville, KY.
Arpit ShahMount Sinai St Luke's & Mount Sinai West Hospitals, New York, NY.
Sameer AtherUniversity of Alabama at Birmingham, Birmingham, AL.
Pedro A LemosHeart Institute (InCor), University of Sao Paulo Medical School, Sao Paulo, Brazil.
Pedro MorenoMount Sinai St Luke's & Mount Sinai West Hospitals, New York, NY.
Gregg W StoneColumbia University Medical Center, New York-Presbyterian Hospital and the Cardiovascular Research Foundation, New York, NY. Electronic address: gs2184@columbia.edu.
NewYork–Presbyterian Hospital · USUniversidade de São Paulo · BRUniversity of Alabama at Birmingham · USUniversity of Louisville · USUniversity of Utah · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The relative outcomes of intravascular ultrasound (IVUS)-guided percutaneous coronary intervention (PCI) compared with angiography-guided PCI with drug-eluting stent (DES) in complex lesions have not been established. We sought to compare the efficacy and safety of IVUS-guided PCI with angiography-guided PCI in patients with complex coronary lesions treated with DES.

methodsElectronic databases were searched to identify all randomized trials comparing IVUS-guided vs angiography-guided DES implantation. We evaluated major adverse cardiac events (MACE), all-cause and cardiovascular death, myocardial infarction, target lesion revascularization (TLR), target vessel revascularization (TVR), and stent thrombosis outcomes at the longest reported follow-up. Random-effects modeling was used to calculate pooled relative risk (RR) and 95% CIs.

resultsEight trials comprising 3,276 patients (1,635 IVUS-guided and 1,641 angiography-guided) enrolling only patients with complex lesions were included. Mean follow-up was 1.4±0.5years. Compared with angiography-guided PCI, patients undergoing IVUS-guided PCI had significantly lower MACE (RR 0.64, 95% CI 0.51-0.80, P=.0001), TLR (RR 0.62, 95% CI 0.45-0.86, P=.004), and TVR (RR 0.60, 95% CI 0.42-0.87, P=.007). There were no significant differences for stent thrombosis, cardiovascular death, or all-cause death. In meta-regression analysis, IVUS-guided PCI was of greatest benefit in reducing MACE in patients with acute coronary syndromes, diabetes, and long lesions.

conclusionsThe present meta-analysis demonstrates a significant reduction in MACE, TVR, and TLR with IVUS-guided DES implantation in complex coronary lesions.

Indexed as

Coronary AngiographyDrug-Eluting StentsUltrasonography, InterventionalCardiovascular DiseasesCause of DeathCoronary Artery DiseaseGraft Occlusion, VascularHumansMortalityMyocardial InfarctionMyocardial RevascularizationPercutaneous Coronary InterventionRandomized Controlled Trials as TopicSurgery, Computer-AssistedThrombosis

Identifiers

PMID28267472
OpenAlexW2556734079

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.