ReviewChest2017
Management of Persistent Air Leaks.
Review in Chest, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 141 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
PATCHVALVE Trial: A Prospective Evaluation of Blood Patch and Endobronchial Valves for Persistent Air Leaks - Pilot Study
Dextrose Pleurodesis Versus Standard of Care for the Management of Post-Operative Air Leak: A Single Center Prospective Trial
Who cites it
141 citing papers in PubMed, 2 syntheses or guidelines pooled it, 289 citations in OpenAlex.
- Recommendations for the standardization and management of prolonged air leaks in lung surgery.European journal of medical research · 2025Pooled it
- Air leak with COVID-19 - A meta-summary.Asian cardiovascular & thoracic annals · 2022Pooled it
- Study Protocol of the Endobronchial VAlves for Pneumothorax to Reduce Admission Time (EVAPoRATe) Pilot Multicentre Randomised Clinical Trial.Respirology case reports · 2026Trial
- Efficacy of Non-Powered Stapler in Lung Volume Reduction Surgery of Severe Lung Emphysema: A Prospective Randomized Single-Blinded Monocentric Study.Interdisciplinary cardiovascular and thoracic surgery · 2026Trial
- Comparison of 40% Glucose Solution and Autologous Blood Patch Pleurodesis for the Treatment of Postoperative Air Leak After Lung Resections: A Prospective Randomized Controlled Study.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2025Trial
- Chest tube removal at different gas flows in prolonged air leak: a randomized non-inferiority trial.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2024Trial
- A series of experiences with TissuePatch™ for alveolar air leak after pulmonary resection.General thoracic and cardiovascular surgery · 2023Trial
- Construction and validation of a nomogram for predicting prolonged air leak after minimally invasive pulmonary resection.World journal of surgical oncology · 2022Trial
- Efficacy and safety profile of autologous blood versus talc pleurodesis for malignant pleural effusion: a randomized controlled trial.Therapeutic advances in respiratory diseaseTrial
- Pulmonary metastasectomy and response-adapted preoperative surveillance in resectable metastatic osteosarcoma: a single-center retrospective cohort study with long-term follow-up.Translational lung cancer research · 2026Article
- From tradition to evidence: a narrative review for standardizing chest tube management after anatomic lung resection.Journal of thoracic disease · 2026Review
- Bronchoscopic Localization of a Post-Surgical Persistent Air Leak Facilitating Successful Treatment With a Hybrid Imaging-Guided Percutaneous Sealing of Fistula and Autologous Blood Patch Technique.Respirology case reports · 2026Article
- Interventional techniques and strategies for postoperative bronchopleural fistula treatment: a narrative review.Journal of thoracic disease · 2026Review
- Early results of robotic versus uniportal video-assisted thoracic complex segmentectomy: a propensity score-matched study.Journal of robotic surgery · 2026Article
- Article
- Endobronchial valves for severe air leak in critically ill children with necrotizing pneumonia requiring extracorporeal membrane oxygenation.Perfusion · 2026Article
- Bronchopleural fistula after lobectomy: retrospective study of different treatment solutions.BMC pulmonary medicine · 2026Article
- Article
- Simultaneous Bilateral Endobronchial Valve Insertion for Management of Persistent Air Leaks Secondary to Necrotising Pneumonia.Respirology case reports · 2026Article
- Optimal suction pressure on digital drainage systems for the management of postoperative air leaks together with IL-2 therapy: a retrospective cohort study.BMC pulmonary medicine · 2026Article
81 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on byResponse.2017
- Commented on byPleurodesis.2017
- Commented on by
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Alveolar-pleural fistulas causing persistent air leaks (PALs) are associated with prolonged hospital stays and high morbidity. Prior guidelines recommend surgical repair as the gold standard for treatment, albeit it is a solution with limited success. In patients who have recently undergone thoracic surgery or in whom surgery would be contraindicated based on the severity of illness, there has been a lack of treatment options. This review describes a brief history of treatment guidelines for PALs. In the past 20 years, newer and less invasive treatment options have been developed. Aside from supportive care, the literature includes anecdotal successful reports using fibrin sealants, ethanol injection, metal coils, and Watanabe spigots. More recently, larger studies have demonstrated success with chemical pleurodesis, autologous blood patch pleurodesis, and endobronchial valves. This manuscript describes these treatment options in detail, including postprocedural adverse events. Further research, including randomized controlled trials with comparison of these options, are needed, as is long-term follow-up for these interventions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.