ArticleeLife2017
Mapping the function of neuronal ion channels in model and experiment.
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Distribution and voltage dependence of ion channels shape single-neuron computations.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Generalised Hodgkin-Huxley model captures human P2X and AMPA receptor currents.The Journal of physiology · 2026Article
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- Biophysical modelling of intrinsic cardiac nervous system neuronal electrophysiology based on single-cell transcriptomics.The Journal of physiology · 2025Article
- The Roles of Potassium and Calcium Currents in the Bistable Firing Transition.Brain sciences · 2023Article
- The Role of Potassium and Calcium Currents in the Bistable Firing Transition.bioRxiv : the preprint server for biology · 2023Article
- The impact of Hodgkin-Huxley models on dendritic research.The Journal of physiology · 2023Review
- NeuroML-DB: Sharing and characterizing data-driven neuroscience models described in NeuroML.PLoS computational biology · 2023Article
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- Reconstruction of the Hippocampus.Advances in experimental medicine and biology · 2022Article
- ChanFAD: A Functional Annotation Database for Ion Channels.Frontiers in bioinformatics · 2022Article
- Computational Concepts for Reconstructing and Simulating Brain Tissue.Advances in experimental medicine and biology · 2022Article
- Predicting Synaptic Connectivity for Large-Scale Microcircuit Simulations Using Snudda.Neuroinformatics · 2021Article
- Data-driven reduction of dendritic morphologies with preserved dendro-somatic responses.eLife · 2021Article
- Training deep neural density estimators to identify mechanistic models of neural dynamics.eLife · 2020Article
- Degeneracy in hippocampal physiology and plasticity.Hippocampus · 2019Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Ion channel models are the building blocks of computational neuron models. Their biological fidelity is therefore crucial for the interpretation of simulations. However, the number of published models, and the lack of standardization, make the comparison of ion channel models with one another and with experimental data difficult. Here, we present a framework for the automated large-scale classification of ion channel models. Using annotated metadata and responses to a set of voltage-clamp protocols, we assigned 2378 models of voltage- and calcium-gated ion channels coded in
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.