ReviewCurrent opinion in organ transplantation2017
Subzero organ preservation: the dawn of a new ice age?
Review in Current opinion in organ transplantation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- Article
- Cryopreservation Strategies to Improve Access to Organ Transplantation.Transplantation · 2026Review
- Organ preservation: current limitations and optimization approaches.Frontiers in medicine · 2025Review
- Beyond the icebox: modern strategies in organ preservation for transplantation.Clinical transplantation and research · 2024Review
- [Advances and perspectives in vascularized composite allotransplantation preservation].Bulletin de l'Academie nationale de medecine · 2024Article
- VCA supercooling in a swine partial hindlimb model.Scientific reports · 2024Article
- Machine Perfusion Enables 24-h Preservation of Vascularized Composite Allografts in a Swine Model of Allotransplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2024Article
- Current practice and novel approaches in organ preservation.Frontiers in transplantation · 2023Review
- Graft preservation in heart transplantation: current approaches.Frontiers in cardiovascular medicine · 2023Review
- Partial freezing of rat livers extends preservation time by 5-fold.Nature communications · 2022Article
- Protection of rat artery grafts from tissue damage by voltage-applied supercooling.Medical molecular morphology · 2022Article
- Preservation of Organs to Be Transplanted: An Essential Step in the Transplant Process.International journal of molecular sciences · 2022Review
- Isochoric supercooled preservation and revival of human cardiac microtissues.Communications biology · 2021Article
- Zebrafish as a New Tool in Heart Preservation Research.Journal of cardiovascular development and disease · 2021Review
- Non-invasive quantification of the mitochondrial redox state in livers during machine perfusion.PloS one · 2021Article
- Whole Ovary Cryopreservation and Transplantation: A Systematic Review of Challenges and Research Developments in Animal Experiments and Humans.Journal of clinical medicine · 2020Review
- Subzero non-frozen preservation of human livers in the supercooled state.Nature protocols · 2020Article
- Supercooling extends preservation time of human livers.Nature biotechnology · 2019Article
- Systems engineering the organ preservation process for transplantation.Current opinion in biotechnology · 2019Review
- Organ Preservation into the 2020s: The Era of Dynamic Intervention.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
purpose of reviewHerein, we review the field of subzero organ preservation with a focus on recent developments in hepatic supercooling. RECENT
findingsOrgan preservation is making a rapid shift from the decade old standard of storage on ice toward techniques that improve organ availability as well as preservation time. Long-term organ preservation would have tremendous benefits to the organ transplantation field, including better organ allocation, donor-recipient matching, as well as reduced preservation injury, and subsequent improvement of donor organ use. The formation of ice has proven an important limiting factor and novel techniques attempt to control or prevent freezing using cryoprotective agents, and highly controlled cooling regimens. Various techniques have been employed over the previous decades, including true organ freezing, vitrification, and subzero nonfreezing or supercooling. For most techniques, successful transplantation following long-term subzero preservation has remained elusive. Supercooling, however, recently delivered the first promising results, yielding survival after up to 4 days of supercooled preservation at -6°C. SUMMARY: As the field of organ preservation undergoes significant development, the field of subzero preservation also receives renewed interest. Although many obstacles remain to be overcome to make subzero preservation feasible, novel techniques are beginning to show their potential in achieving long-term preservation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.