ReviewCurrent opinion in organ transplantation2017
Role of temperature in reconditioning and evaluation of cold preserved kidney and liver grafts.
Review in Current opinion in organ transplantation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 28 citations in OpenAlex.
- A Novel Cooling Device for Kidney Transplant Surgery.Surgical innovation · 2024Article
- Preservation of Organs to Be Transplanted: An Essential Step in the Transplant Process.International journal of molecular sciences · 2022Review
- Kidney temperature during living donor kidney transplantation is associated with short-term measured glomerular filtration rate - a prospective study.Transplant international : official journal of the European Society for Organ Transplantation · 2020Article
- Organ Preservation into the 2020s: The Era of Dynamic Intervention.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2019Review
- Rewarming Injury after Cold Preservation.International journal of molecular sciences · 2019Review
- Cold flush after dynamic liver preservation protects against ischemic changes upon reperfusion - an experimental study.Transplant international : official journal of the European Society for Organ Transplantation · 2019Article
- Barriers and Advances in Kidney Preservation.BioMed research international · 2018Review
- Improved approach for normothermic machine perfusion of cold stored kidney grafts.American journal of translational research · 2018Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewOrgan shortage in transplantation medicine forces surgical research toward the development of more efficient approaches in organ preservation to enable the application of 'less than optimal' grafts. This review summarizes current techniques aiming to recondition cold-stored organ grafts prior to transplantation to reduce reperfusion-induced tissue injury and improve postimplantation graft function. RECENT
findingsEnd-ischemic reconditioning has classically been attempted by cold oxygenated perfusion. By contrast, evaluation of graft performance prior to transplantation might be facilitated by perfusion at higher temperatures, ideally at normothermia. A drastic temperature shift from cold preservation to warm perfusion, however, has been incriminated to trigger a so-called rewarming injury associated with mitochondrial alterations. A controlled gradual warming up during machine perfusion could enhance the restitution of cellular homeostasis and improve functional outcome upon warm reperfusion. SUMMARY: Machine perfusion after conventional cold storage is beneficial for ulterior function after transplantation. Cold grafts should be initially perfused at low temperatures allowing for restitution of cellular homeostasis under protective hypothermic limitation of metabolic turnover. Delayed slow rewarming of the organ might further mitigate rewarming injury upon reperfusion and also increases the predictive power of evaluative measures, taken during pretransplant perfusion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.