Lung injury pathways: Adenosine receptor 2B signaling limits development of ischemic bronchiolitis obliterans organizing pneumonia.
John C Densmore, Terry R Schaid, Paul M Jeziorczak, Meetha Medhora, Said Audi, Shraddha Nayak, John Auchampach, Melinda R Dwinell, Aron M Geurts, Elizabeth R Jacobs
Article in Experimental lung research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
10 authors at 3 institutions in 1 country.
John C Densmorea Children's Research Institute , Milwaukee , Wisconsin , USA.
Terry R Schaidc Medical College of Wisconsin , Milwaukee , Wisconsin , USA.
Paul M Jeziorczaka Children's Research Institute , Milwaukee , Wisconsin , USA.
Meetha Medhorac Medical College of Wisconsin , Milwaukee , Wisconsin , USA.
Said Audid Marquette University , Milwaukee , Wisconsin , USA.
Shraddha Nayakc Medical College of Wisconsin , Milwaukee , Wisconsin , USA.
John Auchampachc Medical College of Wisconsin , Milwaukee , Wisconsin , USA.
Melinda R Dwinellc Medical College of Wisconsin , Milwaukee , Wisconsin , USA.
Aron M Geurtsc Medical College of Wisconsin , Milwaukee , Wisconsin , USA.
Elizabeth R Jacobsb Clinical and Translational Science Institute , Milwaukee , Wisconsin , USA.
Medical College of Wisconsin · USSouthern California Clinical and Translational Science Institute · USMarquette University · US
Funding
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR031973 · NCRR · MEDICAL COLLEGE OF WISCONSIN · PI SHAKER, REZA NONE · 2010 to 2011
$7.9M
Mechanistic characterization of genes for hypertension and renal disease.RC2HL101681 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI JACOB, HOWARD J · 2009 to 2010
$6.6M
Role of Adenosine Receptors in Tissue ProtectionR01HL077707 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI AUCHAMPACH, JOHN A · 2005 to 2014
$3.4M
Development of lisinopril for post-exposure mitigation of late effects from a radU01AI107305 · NIAID · MEDICAL COLLEGE OF WISCONSIN · PI MEDHORA, MEETHA M · 2013 to 2017
$3.0M
EET-Induced Cardioprotection: Role of Opioids and Nitric Oxide (NO)R01HL111392 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI AUCHAMPACH, JOHN A · 2012 to 2016
$2.2M
Innovative Biomarkers to Predict Radiation Lung InjuryR01AI101898 · NIAID · MEDICAL COLLEGE OF WISCONSIN · PI MEDHORA, MEETHA M · 2012 to 2016
$1.9M
SPECT Imaging and Computational Modeling for Assessment of Acute Lung InjuryR15HL129209 · NHLBI · MARQUETTE UNIVERSITY · PI SAID H AUDI · 2015 to 2026
$1.8M
Development of ACE Inhibitor as Countermeasure for Radiation-Induced Lung InjuryRC1AI081294 · NIAID · MEDICAL COLLEGE OF WISCONSIN · PI MEDHORA, MEETHA M · 2008 to 2010
$1.7M
Novel imaging to identify lung mitochondrial injury and predict recoveryR01HL116530 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI JACOBS, ELIZABETH R · 2013 to 2016
$1.1M
Novel Diagnostics to Detect Lung InjuryI01BX001681 · VA · CLEMENT J. ZABLOCKI VA MEDICAL CENTER · PI JACOBS, ELIZABETH R · 2013 to 2016
Purpose/Aim of the Study: Adenosine signaling was studied in bronchiolitis obliterans organizing pneumonia (BOOP) resulting from unilateral lung ischemia. MATERIALS AND
methodsIschemia was achieved by either left main pulmonary artery or complete hilar ligation. Sprague-Dawley (SD) rats, Dahl salt sensitive (SS) rats and SS mutant rat strains containing a mutation in the A
resultsTwenty-four hours after unilateral PA ligation, BAL adenosine concentrations from ischemic lungs were increased relative to contralateral lungs in SD rats. A
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Lung injury pathways: Adenosine receptor 2B signaling limits development of ischemic bronchiolitis obliterans organizing pneumonia. · full record | OpenQuestion