ArticleSmall (Weinheim an der Bergstrasse, Germany)2017
Exploring Protein-Nanoparticle Interactions with Coarse-Grained Protein Folding Models.
Article in Small (Weinheim an der Bergstrasse, Germany), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Determination of protein conformation and orientation at buried solid/liquid interfaces.Chemical science · 2023Article
- Automated Protein Secondary Structure Assignment from CBiomolecules · 2022Article
- Molecular Modeling of Protein Corona Formation and Its Interactions with Nanoparticles and Cell Membranes for Nanomedicine Applications.Pharmaceutics · 2021Review
- Article
- Automation and low-cost proteomics for characterization of the protein corona: experimental methods for big data.Analytical and bioanalytical chemistry · 2020Article
- Multiscale Molecular Dynamics Simulation of Multiple Protein Adsorption on Gold Nanoparticles.International journal of molecular sciences · 2019Article
- Molecular Modeling for Nanomaterial-Biology Interactions: Opportunities, Challenges, and Perspectives.Frontiers in bioengineering and biotechnology · 2019Review
- Nanoparticle-Cell Interactions: Relevance for Public Health.The journal of physical chemistry. B · 2018Review
- Machine Learning and Artificial Intelligence in Nanomedicine.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnologyReview
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Understanding the fundamental biophysics behind protein-nanoparticle (NP) interactions is essential for the design and engineering bio-NP systems. The authors describe the development of a coarse-grained protein-NP model that utilizes a structure centric protein model. A key feature of the protein-NP model is the quantitative inclusion of the hydrophobic character of residues in the protein and their interactions with the NP surface. In addition, the curvature of the NP is taken into account, capturing the protein behavior on NPs of different size. The authors evaluate this model by comparison with experimental results for structure and adsorption of a model protein interacting with an NP. It is demonstrated that the simulation results recapitulate the structure of the small α/β protein GB1 on the NP for data from circular dichroism and fluorescence spectroscopy. In addition, the calculated protein adsorption free energy agrees well with the experimental value. The authors predict the dependence of protein folding on the NP size, surface chemistry, and temperature. The model has the potential to guide NP design efforts by predicting protein behavior on NP surfaces with various chemical properties and curvatures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.