ArticleScientific reports2017
Pupillary responses to short-wavelength light are preserved in aging.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Simulated and natural changes in intraocular transparency selectively affect photoreceptor-specific pupil responses.Scientific reports · 2026Article
- Recovery in pupillometric non-visual functions following chiasmal decompression in pituitary adenoma.Brain communications · 2026Article
- Quantitative automated pupillometry in pseudoexfoliation and evaluation of contributory factors.International ophthalmology · 2025Article
- Review
- Influencing Factors on Pupillary Light Responses as a Biomarker for Local Retinal Function in a Large Normative Cohort.Investigative ophthalmology & visual science · 2024Article
- Preservation of Intrinsically Photosensitive Retinal Ganglion Cells (ipRGCs) in Late Adult Mice: Implications as a Potential Biomarker for Early Onset Ocular Degenerative Diseases.Investigative ophthalmology & visual science · 2024Article
- Pupil responses to colorfulness are selectively reduced in healthy older adults.Scientific reports · 2023Article
- The Beneficial Role of Photobiomodulation in Neurodegenerative Diseases.Biomedicines · 2023Review
- Review on age-related differences in non-visual effects of light: melatonin suppression, circadian phase shift and pupillary light reflex in children to older adults.Journal of physiological anthropology · 2023Review
- Handheld chromatic pupillometry can accurately and rapidly reveal functional loss in glaucoma.The British journal of ophthalmology · 2023Article
- The spectral sensitivity of human circadian phase resetting and melatonin suppression to light changes dynamically with light duration.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Cataract type and pupillary response to blue and white light stimuli.Scientific reports · 2021Article
- Deep learning-based pupil model predicts time and spectral dependent light responses.Scientific reports · 2021Article
- PupilEXT: Flexible Open-Source Platform for High-Resolution Pupillometry in Vision Research.Frontiers in neuroscience · 2021Article
- "Blue Sky Effect": Contextual Influences on Pupil Size During Naturalistic Visual Search.Frontiers in psychology · 2021Article
- Prediction accuracy of L- and M-cone based human pupil light models.Scientific reports · 2020Article
- Chromatic Pupillometry Findings in Alzheimer's Disease.Frontiers in neuroscience · 2020Article
- Effects of low and moderate refractive errors on chromatic pupillometry.Scientific reports · 2019Article
- Light-Induced Pupillary Responses in Alzheimer's Disease.Frontiers in neurology · 2019Review
- Chromatic Pupillometry Methods for Assessing Photoreceptor Health in Retinal and Optic Nerve Diseases.Frontiers in neurology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With aging, less blue light reaches the retina due to gradual yellowing of the lens. This could result in reduced activation of blue light-sensitive melanopsin-containing retinal ganglion cells, which mediate non-visual light responses (e.g., the pupillary light reflex, melatonin suppression, and circadian resetting). Herein, we tested the hypothesis that older individuals show greater impairment of pupillary responses to blue light relative to red light. Dose-response curves for pupillary constriction to 469-nm blue light and 631-nm red light were compared between young normal adults aged 21-30 years (n = 60) and older adults aged ≥50 years (normal, n = 54; mild cataract, n = 107; severe cataract, n = 18). Irrespective of wavelength, pupillary responses were reduced in older individuals and further attenuated by severe, but not mild, cataract. The reduction in pupillary responses was comparable in response to blue light and red light, suggesting that lens yellowing did not selectively reduce melanopsin-dependent light responses. Compensatory mechanisms likely occur in aging that ensure relative constancy of pupillary responses to blue light despite changes in lens transmission.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.