ArticleScientific reports2017
Two dimensional electrophysiological characterization of human pluripotent stem cell-derived cardiomyocyte system.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Towards chamber specific heart-on-a-chip for drug testing applications.Advanced drug delivery reviews · 2020Pooled it
- In silico modelling of multi-electrode arrays for enhancing cardiac drug testing on hiPSC-CM heterogeneous tissues.The Journal of physiology · 2026Article
- Ultrapliable bioelectronic interface for mechanosensitive cardiac electrophysiology.Science advances · 2026Article
- Comprehensive Review of Genetic and Epigenetic Regulation of Fetal Hemoglobin in β-Hemoglobinopathies: From Molecular Mechanisms to Clinical Applications.Mediterranean journal of hematology and infectious diseases · 2026Review
- Development of a robust induced pluripotent stem cell atrial cardiomyocyte differentiation protocol to model atrial arrhythmia.Stem cell research & therapy · 2023Article
- Tissue-embedded stretchable nanoelectronics reveal endothelial cell-mediated electrical maturation of human 3D cardiac microtissues.Science advances · 2023Article
- The Human Induced Pluripotent Stem Cell Test as an Alternative Method for Embryotoxicity Testing.International journal of molecular sciences · 2022Article
- Pacemaker translocations and power laws in 2D stem cell-derived cardiomyocyte cultures.PloS one · 2022Article
- Cardio PyMEA: A user-friendly, open-source Python application for cardiomyocyte microelectrode array analysis.PloS one · 2022Article
- iPSC-Cardiomyocyte Models of Brugada Syndrome-Achievements, Challenges and Future Perspectives.International journal of molecular sciences · 2021Review
- Human amniotic fluid stem cells are able to form embryoid body-like aggregates which performs specific functions: morphological evidences.Histochemistry and cell biology · 2021Article
- Distinct Mitochondrial Remodeling During Mesoderm Differentiation in a Human-Based Stem Cell Model.Frontiers in cell and developmental biology · 2021Article
- A method for differentiating human induced pluripotent stem cells toward functional cardiomyocytes in 96-well microplates.Scientific reports · 2020Article
- Transparent Microelectrode Arrays Fabricated by Ion Beam Assisted Deposition for Neuronal Cell in Vitro Recordings.Micromachines · 2020Article
- Review
- Scalable ultrasmall three-dimensional nanowire transistor probes for intracellular recording.Nature nanotechnology · 2019Article
- Representation of Multiple Cellular Phenotypes Within Tissue-Level Simulations of Cardiac Electrophysiology.Bulletin of mathematical biology · 2019Article
- Geometry-Dependent Arrhythmias in Electrically Excitable Tissues.Cell systems · 2018Article
- Review
- Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes as Models for Cardiac Channelopathies: A Primer for Non-Electrophysiologists.Circulation research · 2018Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Stem cell-derived cardiomyocytes provide a promising tool for human developmental biology, regenerative therapies, disease modeling, and drug discovery. As human pluripotent stem cell-derived cardiomyocytes remain functionally fetal-type, close monitoring of electrophysiological maturation is critical for their further application to biology and translation. However, to date, electrophysiological analyses of stem cell-derived cardiomyocytes has largely been limited by biologically undefined factors including 3D nature of embryoid body, sera from animals, and the feeder cells isolated from mouse. Large variability in the aforementioned systems leads to uncontrollable and irreproducible results, making conclusive studies difficult. In this report, a chemically-defined differentiation regimen and a monolayer cell culture technique was combined with multielectrode arrays for accurate, real-time, and flexible measurement of electrophysiological parameters in translation-ready human cardiomyocytes. Consistent with their natural counterpart, amplitude and dV/dt
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.