Evidence map›Paper›PMID 28266609›Full record

ArticleScientific reports2017

Incidence and risk factors of retreatment after three-monthly aflibercept therapy for exudative age-related macular degeneration.

Wataru Kikushima, Yoichi Sakurada, Seigo Yoneyama, Atsushi Sugiyama, Naohiko Tanabe, Atsuki Kume, Fumihiko Mabuchi, Hiroyuki Iijima

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
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  8. Subfoveal choroidal thickness after brolucizumab therapy for neovascular age-related macular degeneration: a short-term multicenter study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022
    Article
  9. Review
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  11. Clinical characteristics of super stable polypoidal choroidal vasculopathy after initial remission with anti-VEGF monotherapy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021
    Article
  12. Article
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  18. Review
  19. AREDS simplified severity scale as a predictive factor for response to aflibercept therapy for typical neovascular age-related macular degeneration.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Wataru KikushimaDepartment of Ophthalmology, Yamanashi University Chuo Yamanashi, Japan.
Yoichi SakuradaDepartment of Ophthalmology, Yamanashi University Chuo Yamanashi, Japan.
Seigo YoneyamaDepartment of Ophthalmology, Yamanashi University Chuo Yamanashi, Japan.
Atsushi SugiyamaDepartment of Ophthalmology, Yamanashi University Chuo Yamanashi, Japan.
Naohiko TanabeDepartment of Ophthalmology, Yamanashi University Chuo Yamanashi, Japan.
Atsuki KumeDepartment of Ophthalmology, Yamanashi University Chuo Yamanashi, Japan.
Fumihiko MabuchiDepartment of Ophthalmology, Yamanashi University Chuo Yamanashi, Japan.
Hiroyuki IijimaDepartment of Ophthalmology, Yamanashi University Chuo Yamanashi, Japan.
University of Yamanashi · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Though anti-vascular endothelial growth factor therapy has become the standard treatment for exudative age-related macular degeneration (AMD), retreatment after the initial loading injection is inevitable in most eyes with residual or recurrent exudative changes. In the present study, we studied 140 treatment naïve eyes with typical neovascular AMD (n = 71) or polypoidal choroidal vasculopathy (PCV) (n = 69) and investigated the incidence and risk factors of retreatment after 3-monthly intravitreal aflibercept injection for exudative AMD during the 12-month period. At 12 months, best-corrected visual acuity (BCVA) improved significantly from 0.45 ± 0.39 to 0.26 ± 0.33 (P = 4.1 × 10

Indexed as

AgedAged, 80 and overAngiogenesis InhibitorsFemaleHumansIncidenceMacular DegenerationMaleNeovascularization, PathologicReceptors, Vascular Endothelial Growth FactorRecombinant Fusion ProteinsRetreatmentRetrospective StudiesRisk FactorsTreatment OutcomeafliberceptAngiogenesis InhibitorsReceptors, Vascular Endothelial Growth FactorRecombinant Fusion Proteins

Identifiers

PMID28266609
PMCPMC5339812
OpenAlexW2594190858

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.