ArticleScientific reports2017
Autaptic Connections Shift Network Excitability and Bursting.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Article
- Control theory illustrates the energy efficiency in the dynamic reconfiguration of functional connectivity.Communications biology · 2022Article
- Functional Brain Controllability Alterations in Stroke.Frontiers in bioengineering and biotechnology · 2022Article
- NMDA Receptor Alterations After Mild Traumatic Brain Injury Induce Deficits in Memory Acquisition and Recall.Neural computation · 2021Article
- Network structure of cascading neural systems predicts stimulus propagation and recovery.Journal of neural engineering · 2020Article
- A practical guide to methodological considerations in the controllability of structural brain networks.Journal of neural engineering · 2020Article
- Neuronal Degeneration Impairs Rhythms Between Connected Microcircuits.Frontiers in computational neuroscience · 2020Article
- Autaptic Cultures: Methods and Applications.Frontiers in synaptic neuroscience · 2020Article
- Neurodegeneration exposes firing rate dependent effects on oscillation dynamics in computational neural networks.PloS one · 2020Article
- Influence of Autapses on Synchronization in Neural Networks With Chemical Synapses.Frontiers in systems neuroscience · 2020Article
- Temporal lobe epilepsy: Hippocampal pathology modulates connectome topology and controllability.Neurology · 2019Article
- Sex differences in network controllability as a predictor of executive function in youth.NeuroImage · 2019Article
- Critical synchronization and 1/f noise in inhibitory/excitatory rich-club neural networks.Scientific reports · 2019Article
- Structural Insights Into the Dynamic Evolution of Neuronal Networks as Synaptic Density Decreases.Frontiers in neuroscience · 2019Article
- Modeling and interpreting mesoscale network dynamics.NeuroImage · 2018Review
- The Energy Landscape of Neurophysiological Activity Implicit in Brain Network Structure.Scientific reports · 2018Article
- Generative models for network neuroscience: prospects and promise.Journal of the Royal Society, Interface · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
We examine the role of structural autapses, when a neuron synapses onto itself, in driving network-wide bursting behavior. Using a simple spiking model of neuronal activity, we study how autaptic connections affect activity patterns, and evaluate if controllability significantly affects changes in bursting from autaptic connections. Adding more autaptic connections to excitatory neurons increased the number of spiking events and the number of network-wide bursts. We observed excitatory synapses contributed more to bursting behavior than inhibitory synapses. We evaluated if neurons with high average controllability, predicted to push the network into easily achievable states, affected bursting behavior differently than neurons with high modal controllability, thought to influence the network into difficult to reach states. Results show autaptic connections to excitatory neurons with high average controllability led to higher burst frequencies than adding the same number of self-looping connections to neurons with high modal controllability. The number of autapses required to induce bursting was lowered by adding autapses to high degree excitatory neurons. These results suggest a role of autaptic connections in controlling network-wide bursts in diverse cortical and subcortical regions of mammalian brain. Moreover, they open up new avenues for the study of dynamic neurophysiological correlates of structural controllability.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.