ArticleScientific reports2017
ceRNA crosstalk stabilizes protein expression and affects the correlation pattern of interacting proteins.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- The Role of Ovarian Granulosa Cells Related-ncRNAs in Ovarian Dysfunctions: Mechanism Research and Clinical Exploration.Reproductive sciences (Thousand Oaks, Calif.) · 2025Review
- Alcohol consumption and esophageal cancer risk: unveiling DLEU2 as a key immune modulator through Mendelian randomization and transcriptomic analysis.Discover oncology · 2025Article
- MALAT1/miR-320a in bone marrow mesenchymal stem cells function may shed light on mechanisms underlying osteoporosis.Archives of medical science : AMS · 2022Article
- Construction of long non-coding RNA- and microRNA-mediated competing endogenous RNA networks in alcohol-related esophageal cancer.PloS one · 2022Article
- Single-cell Transcriptomes Reveal Characteristics of MicroRNAs in Gene Expression Noise Reduction.Genomics, proteomics & bioinformatics · 2021Article
- Small RNA-driven feed-forward loop: fine-tuning of protein synthesis through sRNA-mediated crosstalk.The European physical journal. E, Soft matter · 2021Article
- Heterogeneity coordinates bacterial multi-gene expression in single cells.PLoS computational biology · 2020Article
- Cross-Talk Between circRNAs and mRNAs Modulates MiRNA-mediated Circuits and Affects Melanoma Plasticity.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2019Article
- Review
- Competing endogenous RNA crosstalk at system level.PLoS computational biology · 2019Article
- FEZF1-AS1: a novel vital oncogenic lncRNA in multiple human malignancies.Bioscience reports · 2019Review
- Stochastic sequestration dynamics: a minimal model with extrinsic noise for bimodal distributions and competitors correlation.Scientific reports · 2018Article
- Construction of an oesophageal cancer-specific ceRNA network based on miRNA, lncRNA, and mRNA expression data.World journal of gastroenterology · 2018Article
- [Research progress of competing endogenous RNA].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2017Review
- TMED2 promotes epithelial ovarian cancer growth.Oncotarget · 2017Article
- Translating ceRNA Susceptibilities into Correlation Functions.Biophysical journal · 2017Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gene expression is a noisy process and several mechanisms, both transcriptional and post-transcriptional, can stabilize protein levels in cells. Much work has focused on the role of miRNAs, showing in particular that miRNA-mediated regulation can buffer expression noise for lowly expressed genes. Here, using in silico simulations and mathematical modeling, we demonstrate that miRNAs can exert a much broader influence on protein levels by orchestrating competition-induced crosstalk between mRNAs. Most notably, we find that miRNA-mediated cross-talk (i) can stabilize protein levels across the full range of gene expression rates, and (ii) modifies the correlation pattern of co-regulated interacting proteins, changing the sign of correlations from negative to positive. The latter feature may constitute a potentially robust signature of the existence of RNA crosstalk induced by endogenous competition for miRNAs in standard cellular conditions.
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Registered trials
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