ArticleScientific reports2017
Mineral Surface Chemistry and Nanoparticle-aggregation Control Membrane Self-Assembly.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed, 49 citations in OpenAlex.
- Hydroxy acid conjugation to lipids increases structural and hydrolytic stability.Nature communications · 2026Article
- Protocell formation on micrometeorites.Scientific reports · 2026Article
- Bentonite-Based Functional Nanoclay Enhances Bacteriophage Therapy against Enteric Infections via Toxin Adsorption and Microbiome Recovery.Biomaterials research · 2026Article
- The dynamics of prebiotic take-off: the transfer of functional RNA communities from mineral surfaces to vesicles.Communications biology · 2025Article
- A Fusion-Growth Protocell Model Based on Vesicle Interactions with Pyrite Particles.Molecules (Basel, Switzerland) · 2024Article
- Analysis of Ti- and Pb-based particles in the aqueous environment of Melbourne (Australia) via single particle ICP-MS.Analytical and bioanalytical chemistry · 2022Article
- Synthesis of lipid membranes for artificial cells.Nature reviews. Chemistry · 2021Review
- Did Solid Surfaces Enable the Origin of Life?Life (Basel, Switzerland) · 2021Article
- Primitive Compartmentalization for the Sustainable Replication of Genetic Molecules.Life (Basel, Switzerland) · 2021Review
- Origin of Species before Origin of Life: The Role of Speciation in Chemical Evolution.Life (Basel, Switzerland) · 2021Review
- Nanoscale Anatomy of Iron-Silica Self-Organized Membranes: Implications for Prebiotic Chemistry.Angewandte Chemie (International ed. in English) · 2021Article
- Development of Novel High-Resolution Size-Guided Turbidimetry-Enabled Particle Purification Liquid Chromatography (PPLC): Extracellular Vesicles and Membraneless Condensates in Focus.International journal of molecular sciences · 2020Article
- Core-Shell Modeling of Light Scattering by Vesicles: Effect of Size, Contents, and Lamellarity.Biophysical journal · 2019Article
- The Paleomineralogy of the Hadean Eon Revisited.Life (Basel, Switzerland) · 2018Review
- Lipid vesicles chaperone an encapsulated RNA aptamer.Nature communications · 2018Article
- Mineral Surface-Templated Self-Assembling Systems: Case Studies from Nanoscience and Surface Science towards Origins of Life Research.Life (Basel, Switzerland) · 2018Review
- Modified Lipid Extraction Methods for Deep Subsurface Shale.Frontiers in microbiology · 2017Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The self-assembly of lipid bilayer membranes to enclose functional biomolecules, thus defining a "protocell," was a seminal moment in the emergence of life on Earth and likely occurred at the micro-environment of the mineral-water interface. Mineral-lipid interactions are also relevant in biomedical, industrial and technological processes. Yet, no structure-activity relationships (SARs) have been identified to predict lipid self-assembly at mineral surfaces. Here we examined the influence of minerals on the self-assembly and survival of vesicles composed of single chain amphiphiles as model protocell membranes. The apparent critical vesicle concentration (CVC) increased in the presence of positively-charged nanoparticulate minerals at high loadings (mg/mL) suggesting unfavorable membrane self-assembly in such situations. Above the CVC, initial vesicle formation rates were faster in the presence of minerals. Rates were correlated with the mineral's isoelectric point (IEP) and reactive surface area. The IEP depends on the crystal structure, chemical composition and surface hydration. Thus, membrane self-assembly showed rational dependence on fundamental mineral properties. Once formed, membrane permeability (integrity) was unaffected by minerals. Suggesting that, protocells could have survived on rock surfaces. These SARs may help predict the formation and survival of protocell membranes on early Earth and other rocky planets, and amphiphile-mineral interactions in diverse other phenomena.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.