ArticleScientific reports2017
Gd-EOB-DTPA-enhanced MRI for evaluation of liver function: Comparison between signal-intensity-based indices and T1 relaxometry.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.
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Who cites it
59 citing papers in PubMed, 1 synthesis or guideline pooled it, 94 citations in OpenAlex.
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- Phase-adaptive automated whole-liver quantification of signal intensity-derived liver indices from gadoxetic acid-enhanced MRI.European radiology experimental · 2026Article
- Cross-Vendor Validation of Proton Density Fat Fraction and TJournal of magnetic resonance imaging : JMRI · 2026Article
- Gadoxetic Acid-Enhanced T1 Mapping Enables Transporter-Mediated Molecular Imaging of Liver Functional Reserve.Biomedicines · 2026Article
- Pharmacokinetic modelling of MRI-based liver function for risk assessment in primary sclerosing cholangitis: a prospective pilot study.European radiology experimental · 2026Article
- Quantitative Assessment of Liver Function Using the Liver Enhancement Ratio on Gadoxetic Acid-Enhanced Magnetic Resonance Imaging in Chronic Liver Disease.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2026Article
- Evaluating the Effect of Sorafenib on Gd-EOB-DTPA-mediated Contrast Enhancement: An Experimental Study using DCE-MRI.Molecular imaging and biology · 2026Article
- Comparative study of Gd-EOB-DTPA-enhanced magnetic resonance imaging signal intensity parameters and albumin-bilirubin grade for liver function assessment based on early and middle-stage of liver dysfunction.Quantitative imaging in medicine and surgery · 2026Article
- Functional Avoidance Liver 4π Stereotactic Body Radiation Therapy Informed by Quantitative Gadoxetic Acid Contrast-Enhanced Magnetic Resonance T1 Mapping.International journal of radiation oncology, biology, physics · 2026Article
- Prediction of hepatic functional reserve using a gadoxetic acid-enhanced MRI-derived 'Severity Index'.BMC medical imaging · 2025Article
- Harmonization of quantitative liver function evaluation using gadoxetate disodium-enhanced magnetic resonance imaging.European radiology · 2025Article
- MRI findings of newly present benign focal hepatic observations following chemotherapy: distinct features in early- and late-term follow-up.European radiology · 2025Article
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- Fat-separated T1 mapping for liver function analysis on gadoxetic acid-enhanced MR imaging: 2D two-point Dixon Look-Locker inversion recovery sequence for differentiation of Child-Pugh class B/C from Child-Pugh class A/chronic liver disease.Quantitative imaging in medicine and surgery · 2025Article
- A concise review of updated global guidelines for the management of hepatocellular carcinoma: 2017-2024.Journal of liver cancer · 2025Article
- Nature of the Intracellular-contrast-enhancing Fat-saturated T1-weighted Gradient-echo (ICE-TIGRE) Sequence: A Fat-suppressed T1-weighted Technique with Motion-sensitised Driven-equilibrium for Improved Contrast Enhancement in Liver Imaging.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025Article
- Development of respiratory motion-resolved hepatobiliary phase cine-magnetic resonance imaging for stereotactic body radiotherapy in liver tumor.Scientific reports · 2024Article
- Influence of Gadoxetate disodium to the hepatic proton density fat fraction quantified with the Dixon sequences in a rabbit model.Abdominal radiology (New York) · 2024Article
- Effect of Sarcopenia on the Increase in Liver Volume and Function After Portal Vein Embolization.Cardiovascular and interventional radiology · 2024Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gadolinium ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA) is a paramagnetic hepatobiliary magnetic resonance (MR) contrast agent. Due to its OATP1B1/B3-dependent hepatocyte-specific uptake and paramagnetic properties increasing evidence has emerged to suggest that Gd-EOB-DTPA-enhanced MRI can be potentially used for evaluation of liver function. In this paper we compare the diagnostic performance of Gd-EOB-DTPA-enhanced relaxometry-based and commonly used signal-intensity (SI)-based indices, including the hepatocellular uptake index (HUI) and SI-based indices corrected by spleen or muscle, for evaluation of liver function, determined using the Indocyanin green clearance (ICG) test. Simple linear regression model showed a significant correlation of the plasma disappearance rate of ICG (ICG-PDR) with all Gd-EOB-DTPA-enhanced MRI-based liver function indices with a significantly better correlation of relaxometry-based indices on ICG-PDR compared to SI-based indices. Among SI-based indices, HUI achieved best correlation on ICG-PDR and no significant difference of respective correlations on ICG-PDR could be shown. Assessment of liver volume and consecutive evaluation of multiple linear regression model revealed a stronger correlation of ICG-PDR with both (SI)-based and T1 relaxometry-based indices. Thus, liver function can be estimated quantitatively from Gd-EOB-DTPA-enhanced MRI-based indices. Here, indices derived from T1 relaxometry are superior to SI-based indices, and all indices benefit from taking into account respective liver volumes.
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