ArticleInternational wound journal2017
Effectiveness of a polyhexanide irrigation solution on methicillin-resistant Staphylococcus aureus biofilms in a porcine wound model.
Article in International wound journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Effects of Extended-Release Polyhexanide on Inflammatory Cytokine Expression and Disease Severity Following Staphylococcus Aureus Exposure in a Murine Dermatitis Model.Life (Basel, Switzerland) · 2026Article
- Cold Atmospheric Plasma Disrupts Microbial Wound Bioburden: In Vitro, Porcine MRSA Biofilm, and Clinical Fluorescence Evidence from Bench to Bedside.Biomedicines · 2026Article
- In Vitro and In Vivo Comparison of a Novel Antimicrobial Wound Hydrogel With Commercial Wound Treatments: Antimicrobial, Antibiofilm and Biocompatibility Assessment.International wound journal · 2026Article
- Tailored Negative Pressure Wound Therapy with instillation in diabetic, hypertensive, and obese patients-when guideline treatment is not enough: a case series and a proposal for the ANSWER score.World journal of emergency surgery : WJES · 2025Article
- An Antimicrobial Blue Light Prototype Device Controls Infected Wounds in a Preclinical Porcine Model.The Journal of infectious diseases · 2025Article
- Impact of Interfering Substances on the Bactericidal Efficacy of Different Commercially Available Hypochlorous Acid-Based Wound Irrigation Solutions Commonly Found in South-East Asia.Antibiotics (Basel, Switzerland) · 2024Article
- Insights into the mechanisms of diabetic wounds: pathophysiology, molecular targets, and treatment strategies through conventional and alternative therapies.Inflammopharmacology · 2024Review
- Effect of Commercially Available Wound Irrigation Solutions on Uninfected Host Tissue in a Murine Model.Arthroplasty today · 2024Article
- Comparison of antimicrobial efficacy and therapeutic index properties for common wound cleansing solutions, focusing on solutions containing PHMB.GMS hygiene and infection control · 2024Article
- The efficacy of a nitric oxide-releasing formulation on nares isolated Methicillin-ResistantFrontiers in cellular and infection microbiology · 2024Article
- The Effectiveness of Polyhexanide in Treating Wound Infections Due to Methicillin-Resistant Staphylococcus Aureus: A Prospective Analysis.Infection and drug resistance · 2024Article
- Irrigation in Endodontics: Polyhexanide Is a Promising Antibacterial Polymer in Root Canal Treatment.Dentistry journal · 2023Review
- Antiseptic-Loaded Casein Hydrogels for Wound Dressings.Pharmaceutics · 2023Article
- Biofilm-Associated Infections in Chronic Wounds and Their Management.Advances in experimental medicine and biology · 2023Article
- Antimicrobial efficacy of composite irrigation solution against dominant pathogens in seawater immersion wound andFrontiers in microbiology · 2023Article
- 3D Biofilm Models Containing Multiple Species for Antimicrobial Testing of Wound Dressings.Microorganisms · 2022Article
- Advanced Wound Diagnostics: Toward Transforming Wound Care into Precision Medicine.Advances in wound care · 2022Review
- Antimicrobial effectiveness of wound matrices containing native extracellular matrix with polyhexamethylene biguanide.International wound journal · 2022Article
- Irrigation Solutions in Total Joint Arthroplasty.Spartan medical research journal · 2022Article
- Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Irrigation and removal of necrotic debris can be beneficial for proper healing. It is becoming increasingly evident that wounds colonized with biofilm forming bacteria, such as Staphylococcus aureus (SA), can be more difficult to eradicate. Here we report our findings of the effects of an irrigation solution containing propyl-betaine and polyhexanide (PHMB) on methicillin-resistant Staphylococcus aureus (MRSA) biofilms in a porcine wound model. Thirty-nine deep partial thickness wounds were created with six wounds assigned to one of six treatment groups: (i) PHMB, (ii) Ringer's solution, (iii) hypochlorous acid/sodium hypochlorite, (iv) sterile water, (v) octenidine dihydrochloride, and (vi) octenilin. Wounds were inoculated with MRSA and covered with a polyurethane dressing for 24 hours to allow biofilm formation. The dressings were then removed and the wounds were irrigated twice daily for 3 days with the appropriate solution. MRSA from four wounds were recovered from each treatment group at 3 days and 6 days hours after initial treatment. Irrigation of wounds with the PHMB solution resulted in 97·85% and 99·64% reductions of MRSA at the respective 3 days and 6 days assessment times when compared to the untreated group. Both of these reductions were statistically significant compared to all other treatment groups (P values <0·05).
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