Observational studyInternational urology and nephrology2017
Hypophosphatemia: nutritional status, body composition, and mortality in hemodialysis patients.
Observational study in International urology and nephrology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Lean tissue mass is associated with adverse outcomes across different stages of chronic kidney disease: a systematic review and meta-analysis.Scientific reports · 2026Pooled it
- Hypophosphatemia in Coronavirus Disease 2019 (COVID-19), Complications, and Considerations: A Systematic Review.BioMed research international · 2022Pooled it
- An International Expert Consensus Statement and Guidance Document on Implementation of Nutritional Supplementation in Patients on Dialysis.Kidney international reports · 2026Article
- Sarcopenia and 24-Month All-Cause Mortality in Patients Receiving Maintenance Hemodialysis: A Prospective Observational Cohort Study Applying the Revised European Working Group on Sarcopenia in Older People Criteria.Medicina (Kaunas, Lithuania) · 2026Observational
- Phosphorus modifies the association between body mass index and uric acid: Results from NHANES 2007-2018.PloS one · 2024Article
- Changing trend of neonatal Ca/P/Mg status in a Chinese population.Translational pediatrics · 2023Article
- Hypo- and Hyperphosphatemia at Admission as Independent Factors of Mortality of COVID-19 Patients: Findings from a Retrospective Cohort Study.International journal of endocrinology and metabolism · 2022Article
- Dietary Advice in Hemodialysis Patients: Impact of a Telehealth Approach During the COVID-19 Pandemic.Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation · 2022Observational
- Hypophosphatemia after hemodialysis and its association with some clinical complications in patients with chronic kidney disease.Caspian journal of internal medicine · 2022Article
- Association of lactate dehydrogenase with mortality in incident hemodialysis patients.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2021Article
- Hypophosphatemia at Admission is Associated with Increased Mortality in COVID-19 Patients.International journal of general medicine · 2021Article
- Relationship between serum phosphate levels and survival in chronic hemodialysis patients: interactions with age, malnutrition and inflammation.Clinical kidney journal · 2021Article
- A novel approach to dry weight adjustments for dialysis patients using machine learning.PloS one · 2021Article
- A Pooled Analysis of Serum Phosphate Measurements and Potential Hypophosphataemia Events in 45 Interventional Trials with Ferric Carboxymaltose.Journal of clinical medicine · 2020Article
- Mineral and bone disorder in hemodialysis patients in the Tibetan Plateau: a multicenter cross-sectional study.Renal failure · 2019Article
- The authors' reply.Kidney research and clinical practice · 2018Article
- Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of the present study was to investigate the relationship between serum phosphate levels, clinical parameters, body composition, and mortality.
methodsMulticenter longitudinal observational study of a cohort of 3552 patients in hemodialysis (HD) from 34 Nephrocare dialysis units in Portugal with 24 months of follow-up. Patients were divided into three groups depending on their serum phosphorus (<3.5; 3.5-5.5; >5.5 mg/dL). Statistical tests were performed with SPSS, version 20.0. A p < 0.05 was considered significant.
resultsOn the one hand, hypophosphatemia was significantly associated with better dialysis adequacy, higher age and overhydration. On the other hand, it was associated with lower albumin, protein intake, creatinine, hemoglobin, calcium, potassium, magnesium, body mass index (BMI), body cell mass index, fat tissue index and lean tissue index. These patients had lower survival rates compared with those with normo- and hyperphosphatemia. Hypophosphatemia was a predictor of death when adjusted for age, diabetes, HD vintage, gender, and Kt/V. Comparing the mortality predictors in hypo- and hyperphosphatemia, we found that low albumin, BMI, and high overhydration increased the mortality risk in the hypophosphatemic group, whereas in hyperphosphatemic patients data were not statistically significant.
conclusionCurrently, a high prevalence of hypophosphatemia exists in Portuguese HD patients. This condition is associated with worst nutritional and body composition parameters. In the context of additional indices of malnutrition (low albumin, low BMI or severe overhydration), hypophosphatemic patients presented higher mortality risk.
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