Evidence map›Paper›PMID 28265828›Full record

ArticleDigestive diseases and sciences2017

Liver Regeneration Is Impaired in Mice with Acute Exposure to a Very Low Carbohydrate Diet.

Hao Chen, Yandie Lin, Wu Sun, Yun Cai, Hao Li

Abstract read
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In one paragraph

Article in Digestive diseases and sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Hao ChenKey Laboratory of Cardiovascular Disease and Molecular Intervention, Department of Pathophysiology, Nanjing Medical University, Xuehai Building, Room A315, 101 Longmian Road, Jiangning District, Nanjing, 211166, China.
Yandie LinKey Laboratory of Cardiovascular Disease and Molecular Intervention, Department of Pathophysiology, Nanjing Medical University, Xuehai Building, Room A315, 101 Longmian Road, Jiangning District, Nanjing, 211166, China.
Wu SunKey Laboratory of Cardiovascular Disease and Molecular Intervention, Department of Pathophysiology, Nanjing Medical University, Xuehai Building, Room A315, 101 Longmian Road, Jiangning District, Nanjing, 211166, China.
Yun CaiKey Laboratory of Cardiovascular Disease and Molecular Intervention, Department of Pathophysiology, Nanjing Medical University, Xuehai Building, Room A315, 101 Longmian Road, Jiangning District, Nanjing, 211166, China.
Hao LiKey Laboratory of Cardiovascular Disease and Molecular Intervention, Department of Pathophysiology, Nanjing Medical University, Xuehai Building, Room A315, 101 Longmian Road, Jiangning District, Nanjing, 211166, China. haoli@njmu.edu.cn.ORCID 0000-0002-5965-8283
Nanjing Medical University · CNHohai University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe metabolic response to hepatic insufficiency has been implicated in the regulators of normal liver regeneration. Modulation of nutritional factors has been demonstrated to affect liver regeneration. Diets containing very low carbohydrate and high fat levels cause a unique metabolic state, the effect of which on liver regeneration is unknown.

methodsMice were placed on standard mice chow (ND) or a very low carbohydrate diet (VLCD) after 70% partial hepatectomy (PH). After 48 h, mice on VLCD were placed back to ND. The serum metabolic profiles, hepatic lipid content, and gene expression profile were examined. The dynamics of liver regeneration were detected at timed points. Activation of signaling pathways was examined.

resultsVLCD feeding caused hypoglycemia and elevation of serum β-hydroxybutyrate and free fatty acids in mice after PH. It increased hepatic triglyceride contents, enhanced fatty acid oxidation, and reduced lipid synthesis. Mice on VLCD exhibited diminished hepatocellular mitotic frequency, a reduced BrdU incorporation and liver mass regeneration ratio, and delayed expression of PCNA. Expressions of IL-6 and TNFα in liver and serum were downregulated. Meanwhile, phosphorylation of STAT3, Erk, and AKT was delayed compared with controls.

conclusionsVLCD feeding delayed liver regeneration, probably because of the suppression of TNFα-IL-6-STAT3 signaling and delayed activation of Erk and AKT induced by the unique metabolic effects of this diet.

Indexed as

Animal FeedAnimalsDietDietary CarbohydratesGene Expression RegulationHepatectomyInterleukin-6Liver RegenerationMaleMiceMice, Inbred BALB CSignal TransductionSTAT3 Transcription FactorTranscriptomeTumor Necrosis Factor-alphaDietary CarbohydratesInterleukin-6Stat3 protein, mouseSTAT3 Transcription FactorTumor Necrosis Factor-alphaHepatectomyKetogenic dietLiver regenerationLow carbohydrate dietMetabolism

Identifiers

PMID28265828
OpenAlexW2593246977

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.