Evidence map›Paper›PMID 28265714›Full record

ReviewPsychopharmacology2017

A short history of the 5-HT

Jose M Palacios, Angel Pazos, Daniel Hoyer

Registry-linked trialOpen access · greenAbstract readReview
PubMed Publisher
In one paragraph

Review in Psychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03192995 (Treatment With Lorcaserin for Cocaine Use), which is not on this map. Cited by 42 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 2 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03192995 phase2terminatednot on this mapstarted 2018, after this paper: background citation

Treatment With Lorcaserin for Cocaine Use: The TLC Study

TypeinterventionalSponsorGlenn-Milo SantosRan2018 to 2020Enrolled22ConditionsCocaine Use DisorderArmslorcaserin, Placebo Oral Tablet, Substance use counseling, ACASI, Cocaine metabolites
3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 86 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Review
  7. Article
  8. The Relationship Between Oxytocin and Alcohol Dependence.Current topics in behavioral neurosciences · 2025
    Review
  9. Article
  10. Beyond the 5-HTThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Review
  11. Structure activity relationships of 5-HTEuropean journal of medicinal chemistry · 2023
    Article
  12. Review
  13. The neural basis of psychedelic action.Nature neuroscience · 2022
    Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Jose M PalaciosFrontera Biotechnology SL, 08013, Barcelona, Spain.
Angel PazosInstituto de Biomedicina y Biotecnología de Cantabria, IBBTEC, Universidad de Cantabria, CSIC, SODERCAN, Centro de Investigación Biomédica en Red de Salud Mental CIBERSAM, Santander, 39011, Spain.
Daniel HoyerDepartment of Pharmacology and Therapeutics, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC, 3010, Australia. d.hoyer@unimelb.edu.au.
Instituto de Biomedicina y Biotecnología de Cantabria · ESUniversity of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This paper is a personal account on the discovery and characterization of the 5-HT

Indexed as

AnimalsAntidepressive AgentsBehavior, AddictiveBrainChoroid PlexusDepressionGenome-Wide Association StudyHumansObesityReceptor, Serotonin, 5-HT2CSerotonin 5-HT2 Receptor AgonistsSerotonin 5-HT2 Receptor AntagonistsTreatment OutcomeAntidepressive AgentsReceptor, Serotonin, 5-HT2CSerotonin 5-HT2 Receptor AgonistsSerotonin 5-HT2 Receptor Antagonists5-HT2C receptorAgomelatineAnxietyDepressionDrug addictionsGPCRGWASHeteromersHuman brainIn situ hybridizationLorcaserinMesulergineObesityReceptor autoradiographyReceptor homomersRNA editingSchizophreniaSertindoleSmoking cessationSpecies differencesSpinal cord injurySuicideVabicaserin

Identifiers

PMID28265714
OpenAlexW2592469547

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.