ArticleExperimental brain research2017
Activation of the thalamic parafascicular nucleus by electrical stimulation of the peripheral vestibular nerve in rats.
Article in Experimental brain research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 8 citations in OpenAlex.
- Vestibular dysfunction in Parkinson's disease: a neglected topic.Frontiers in neurology · 2024Review
- Frequency-Specific Effects of Galvanic Vestibular Stimulation on Response-Time Performance in Parkinson's Disease.Frontiers in neurology · 2021Article
- Modeling Vestibular Compensation: Neural Plasticity Upon Thalamic Lesion.Frontiers in neurology · 2020Article
- Reducing Neuron Apoptosis in the Pontine Micturition Center by Nerve Root Transfer for Restoration of Micturition Function after Spinal Cord Injury.BioMed research international · 2020Article
- Single neuron activity and c-Fos expression in the rat striatum following electrical stimulation of the peripheral vestibular system.Physiological reports · 2018Article
- The effects of electrical stimulation of the peripheral vestibular system on neurochemical release in the rat striatum.PloS one · 2018Article
- Vestibular Functions and Parkinson's Disease.Frontiers in neurology · 2018Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The parafascicular nucleus (PFN) of the thalamus is a primary structure in the feedback circuit of the basal ganglia-thalamo-cortical system, as well as in the neural circuit of the vestibulo-thalamo-striatal pathway. We investigated the characteristics of the functional connectivity between the peripheral vestibular system and the PFN in rats. A single electrical stimulation was applied to the horizontal semicircular canal nerve in the peripheral vestibular end-organs. This resulted in polysynaptic local field potentials (LFPs) in the PFN, which were composed of long-lasting multiple waves. The LFPs were prominently seen contralateral to the stimulation site. The PFN LFPs were suppressed by transient chemical de-afferentation of peripheral vestibular activity using a 5% lidocaine injection into the middle ear. The spontaneous firing rate of the single units increased after electrical stimulation to the horizontal canal nerve in a frequency-dependent manner. The induction of cFos protein was more prominent in the contralateral PFN than in the ipsilateral PFN following horizontal semicircular canal nerve stimulation. The functional vestibulo-parafascicular connection is a neural substrate for the transmission of vestibular sensory information to the basal ganglia.
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