ReviewJournal of clinical movement disorders2017
Diagnosing the frontal variant of Alzheimer's disease: a clinician's yellow brick road.
Review in Journal of clinical movement disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Phonological and Semantic Fluency in Alzheimer's Disease: A Systematic Review and Meta-Analysis.Journal of Alzheimer's disease : JAD · 2023Pooled it
- Integration of Genetic and Imaging Data for Alzheimer's Disease Diagnosis and Interpretation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Contrastive Brain Network Learning via Hierarchical Signed Graph Pooling Model.IEEE transactions on neural networks and learning systems · 2024Article
- Case report: Rapidly progressive neurocognitive disorder with a fatal outcome in a patient with PU.1 mutated agammaglobulinemia.Frontiers in immunology · 2024Article
- Domain-specific cognitive impairment is differentially affected by Alzheimer disease tau pathologic burden and spread.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Dissecting the clinical heterogeneity of early-onset Alzheimer's disease.Molecular psychiatry · 2022Review
- Neuropsychological and Neuroanatomical Features of Patients with Behavioral/Dysexecutive Variant Alzheimer's Disease (AD): A Comparison to Behavioral Variant Frontotemporal Dementia and Amnestic AD Groups.Journal of Alzheimer's disease : JAD · 2022Article
- Alzheimer's Disease-Related Metabolic Pattern in Diverse Forms of Neurodegenerative Diseases.Diagnostics (Basel, Switzerland) · 2021Article
- Multidimensional Clinical Assessment in Frontotemporal Dementia and Its Spectrum in Latin America and the Caribbean: A Narrative Review and a Glance at Future Challenges.Frontiers in neurology · 2021Review
- Machine Learning Driven Profiling of Cerebrospinal Fluid Core Biomarkers in Alzheimer's Disease and Other Neurological Disorders.Frontiers in neuroscience · 2021Article
- Inter- and Intra-Scanner Variability of Automated Brain Volumetry on Three Magnetic Resonance Imaging Systems in Alzheimer's Disease and Controls.Frontiers in aging neuroscience · 2021Article
- Decision-Making Support for People With Alzheimer's Disease: A Narrative Review.Frontiers in psychology · 2021Review
- Frontal variant of Alzheimer's disease with asymmetric presentation mimicking frontotemporal dementia: Case report and literature review.Brain and behavior · 2020Review
- Alzheimer's Disease or Behavioral Variant Frontotemporal Dementia? Review of Key Points Toward an Accurate Clinical and Neuropsychological Diagnosis.Journal of Alzheimer's disease : JAD · 2020Review
- Protein network analysis reveals selectively vulnerable regions and biological processes in FTD.Neurology. Genetics · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDisruption of the frontal lobes and its associated networks are a common consequence of neurodegenerative disorders. Given the wide range of cognitive, behavioral and motor processes in which the frontal lobes are involved, there can be a great variety of manifestations depending on the pathology distribution. The most common are the behavioral variant of frontotemporal dementia (bvFTD) and the frontal variant of Alzheimer's disease (fvAD), which are particularly challenging to disentangle. Recognizing fvAD from bvFTD-related pathologies is a diagnostic challenge and a critical need in the management and counseling of these patients. CASE PRESENTATION: Here we present three pathology-proven cases of Alzheimer's disease initially misdiagnosed as bvFTD and discuss the distinctive or less overlapping historical, examination, and laboratory findings of fvAD and bvFTD, deriving analogies for mnemonic endurance from the Wizard of Oz worldview.
conclusionThe Yellow Brick Road to diagnosing these disorders may be served by the metaphor of fvAD as the irritable, paranoid, and tremulous Scarecrow and bvFTD the heartless, ritualistic, and rigid Tin Man. An Oz-inspired creative license may help the clinician recognize the differential disease progression, caregiver burden, and treatment response of fvAD compared with bvFTD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.