ArticleCase reports in medicine2017
Pernicious Anemia Associated Cobalamin Deficiency and Thrombotic Microangiopathy: Case Report and Review of the Literature.
Article in Case reports in medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Article
- Vitamin BBMJ case reports · 2023Article
- Article
- Elevated IL-19 Serum Levels in Patients With Pernicious Anemia and Autoimmune Gastritis.Frontiers in immunology · 2022Article
- Pseudo-thrombotic Microangiopathy Caused by Acquired Cobalamin Deficiency Due to Unintentional Neglect.Internal medicine (Tokyo, Japan) · 2021Article
- Article
- Review
- The doctor who stared at schistocytes: an intriguing case of suspected thrombotic microangiopathic anemia.Internal and emergency medicine · 2021Article
- Article
- Article
- Pancytopenia and TTP-like picture secondary to pernicious anaemia.BMJ case reports · 2020Article
- Suspected Metformin-induced Cobalamin Deficiency Mimicking Thrombotic Thrombocytopenic Purpura.Cureus · 2020Article
- Myxedema Coma Complicated by Pancytopenia.Case reports in medicine · 2019Article
- A Rare Cause of Thrombotic Thrombocytopenia Purpura- (TTP-) Like Syndrome, Vitamin B12 Deficiency: Interpretation of Significant Pathological Findings.Case reports in hematology · 2019Article
- Vitamin BJournal of medical case reports · 2018Article
- Thrombocytopenia in hospitalized patients: approach to the patient with thrombotic microangiopathy.Hematology. American Society of Hematology. Education Program · 2017Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A 43-year-old Hispanic male without significant previous medical history was brought to emergency department for syncope following a blood draw to investigate a 40 lbs weight loss during the past 6 months associated with decreased appetite and progressive fatigue. The patient also reported a 1-month history of jaundice. On examination, he was hemodynamically stable and afebrile with pallor and diffuse jaundice but without skin rash or palpable purpura. Normal sensations and power in all extremities were evident on neurological exam. Presence of hemolytic anemia, schistocytosis, thrombocytopenia, and elevated lactate dehydrogenase (LDH) was suggestive of thrombotic thrombocytopenic purpura (TTP). However, presence of leukopenia, macrocytes, and an inadequate reticulocyte response to the degree of anemia served as initial clues to an alternative diagnosis. Two and one units of packed red blood cells were transfused on day 1 and day 3, respectively. In addition, one unit of platelets was transfused on day 2. Daily therapeutic plasma exchange (TPE) was initiated and continued until ADAMTS-13 result ruled out TTP. A low cobalamin (vitamin B12) level was evident at initial laboratory work-up and subsequent testing revealed positive intrinsic factor-blocking antibodies supporting a diagnosis of pernicious anemia with severe cobalamin deficiency. Hematological improvement was observed following vitamin B12 supplementation. The patient was discharged and markedly improved on day 9 with outpatient follow-up for cobalamin supplementation.
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Registered trials
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