Evidence map›Paper›PMID 28265091›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Conserved forkhead dimerization motif controls DNA replication timing and spatial organization of chromosomes in

A Zachary Ostrow, Reza Kalhor, Yan Gan, Sandra K Villwock, Christian Linke, Matteo Barberis, Lin Chen, Oscar M Aparicio

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 52 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. A Fkh1/2 binding site array in thebioRxiv : the preprint server for biology · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Broadly Applicable Control Approaches Improve Accuracy of ChIP-Seq Data.International journal of molecular sciences · 2023
    Article
  13. Review
  14. Article
  15. Rpd3 regulates single-copy origins independently of the rDNA array by opposing Fkh1-mediated origin stimulation.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  16. Article
  17. Unveiling Forkhead-mediated regulation of yeast cell cycle and metabolic networks.Computational and structural biotechnology journal · 2022
    Article
  18. Article
  19. Review
  20. Mammalian DNA Replication Timing.Cold Spring Harbor perspectives in biology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

A Zachary OstrowMolecular and Computational Biology Program, University of Southern California, Los Angeles, CA 90089-2910.
Reza KalhorMolecular and Computational Biology Program, University of Southern California, Los Angeles, CA 90089-2910.ORCID 0000-0002-5558-7545
Yan GanMolecular and Computational Biology Program, University of Southern California, Los Angeles, CA 90089-2910.
Sandra K VillwockMolecular and Computational Biology Program, University of Southern California, Los Angeles, CA 90089-2910.
Christian LinkeSynthetic Systems Biology and Nuclear Organization, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam 1098 XH, The Netherlands.
Matteo BarberisSynthetic Systems Biology and Nuclear Organization, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam 1098 XH, The Netherlands m.barberis@uva.nl.
Lin ChenMolecular and Computational Biology Program, University of Southern California, Los Angeles, CA 90089-2910.
Oscar M AparicioMolecular and Computational Biology Program, University of Southern California, Los Angeles, CA 90089-2910; oaparici@usc.edu.
University of Southern California · USUniversity of Amsterdam · NL

Funding

USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Fumito Ito · 1985 to 2026
$181.4M
Implications of haplotype structure in the human genomeP50HG002790 · NHGRI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TAVARE, SIMON · 2003 to 2013
$29.9M
Regulation of Chromosomal DNA Replication Dynamics in S. CerevisiaeR01GM065494 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI APARICIO, OSCAR M · 2003 to 2022
$6.9M
NCI NIH HHS P30 CA014089NHGRI NIH HHS P50 HG002790NIGMS NIH HHS R01 GM065494
6 · The paper itself

Abstract

Forkhead Box (Fox) proteins share the Forkhead domain, a winged-helix DNA binding module, which is conserved among eukaryotes from yeast to humans. These sequence-specific DNA binding proteins have been primarily characterized as transcription factors regulating diverse cellular processes from cell cycle control to developmental fate, deregulation of which contributes to developmental defects, cancer, and aging. We recently identified

Indexed as

DNA Replication TimingAmino Acid MotifsAmino Acid SequenceCell Cycle ProteinsChromosomes, FungalDimerizationForkhead Transcription FactorsG1 PhaseGene Expression Regulation, FungalHumansMolecular Sequence DataReplication OriginSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSequence AlignmentS PhaseCell Cycle ProteinsFkh1 protein, S cerevisiaeFkh2 protein, S cerevisiaeForkhead Transcription FactorsFOXP2 protein, humanFOXP3 protein, humanSaccharomyces cerevisiae ProteinschromatinDNA binding proteinDNA replication timingFox proteinsnuclear organization

Identifiers

PMID28265091
PMCPMC5373409
OpenAlexW2591864148

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.