Evidence map›Paper›PMID 28265055›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Glyoxylate detoxification is an essential function of malate synthase required for carbon assimilation in

Susan Puckett, Carolina Trujillo, Zhe Wang, Hyungjin Eoh, Thomas R Ioerger, Inna Krieger, James Sacchettini, Dirk Schnappinger, Kyu Y Rhee, Sabine Ehrt

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 97 citations in OpenAlex.

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  6. Study on the phosphorylation of NADJournal of enzyme inhibition and medicinal chemistry · 2025
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  10. Inhibitors of the Thioesterase Activity ofACS infectious diseases · 2024
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  12. Metabolic Rewiring ofMetabolites · 2024
    Review
  13. Article
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  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Microorganisms · 2022
    Review

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Susan PuckettDepartment of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10021.
Carolina TrujilloDepartment of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10021.
Zhe WangDepartment of Medicine, Weill Cornell Medical College, New York, NY 10021.
Hyungjin EohDepartment of Medicine, Weill Cornell Medical College, New York, NY 10021.
Thomas R IoergerDepartment of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843.
Inna KriegerDepartment of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843.
James SacchettiniDepartment of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843.
Dirk SchnappingerDepartment of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10021.
Kyu Y RheeDepartment of Medicine, Weill Cornell Medical College, New York, NY 10021; sae2004@med.cornell.edu kyr9001@med.cornell.edu.
Sabine EhrtDepartment of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10021; sae2004@med.cornell.edu kyr9001@med.cornell.edu.
Cornell University · USTexas A&M University · US

Funding

Viable but Nonculturable MtbU19AI111143 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI GLICKMAN, MICHAEL S, NATHAN, CARL FRANCIS · 2014 to 2020
$48.6M
IMMUNOLOGY RESEARCH TRAINING PROGRAMT32AI007621 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI CESARMAN, ETHEL · 1999 to 2014
$3.4M
Drug targets in Mtb GluconeogenesisR01AI092573 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI EHRT, SABINE · 2011 to 2015
$3.0M
NIAID NIH HHS R01 AI092573NIAID NIH HHS T32 AI007621NIAID NIH HHS U19 AI111143
6 · The paper itself

Abstract

The glyoxylate shunt is a metabolic pathway of bacteria, fungi, and plants used to assimilate even-chain fatty acids (FAs) and has been implicated in persistence of

Indexed as

Inactivation, MetabolicAnimalsCarbonDisease Models, AnimalFatty AcidsFemaleGene Knockout TechniquesGlyoxylatesMacrophagesMalate SynthaseMetabolic Networks and PathwaysMiceMutationMycobacterium tuberculosisTuberculosisVirulenceCarbonFatty AcidsGlyoxylatesMalate Synthaseglyoxylate detoxificationmalate synthasemetabolismtuberculosis

Identifiers

PMID28265055
PMCPMC5358392
OpenAlexW2594077946

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.