Evidence map›Paper›PMID 28265002›Full record

ArticleMolecular and cellular biology2017

Deletion of

Deborah A Zygmunt, Neha Singhal, Mi-Lyang Kim, Megan L Cramer, Kelly E Crowe, Rui Xu, Ying Jia, Jessica Adair, Isabel Martinez-Pena Y Valenzuela, Mohammed Akaaboune and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Molecular and cellular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 14 citations in OpenAlex.

  1. Molecular Framework of the Onset and Progression of Skeletal Muscle Aging.International journal of molecular sciences · 2025
    Review
  2. Article
  3. Review
  4. Review
  5. Therapeutic efficacy of rscAAVrh74.miniCMV.Molecular therapy. Methods & clinical development · 2022
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. A CTG repeat-selective chemical screen identifies microtubule inhibitors as selective modulators of toxic CUG RNA levels.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Deborah A ZygmuntCenter for Gene Therapy, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.
Neha SinghalCenter for Gene Therapy, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.
Mi-Lyang KimCenter for Gene Therapy, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.
Megan L CramerCenter for Gene Therapy, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.
Kelly E CroweCenter for Gene Therapy, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.
Rui XuCenter for Gene Therapy, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.
Ying JiaCenter for Gene Therapy, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.
Jessica AdairCenter for Gene Therapy, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.
Isabel Martinez-Pena Y ValenzuelaDepartment of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA.
Mohammed AkaabouneDepartment of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA.
Peter WhiteCenter for Human Genetics, Nationwide Children's Hospital, Columbus, Ohio, USA.
Paulus M JanssenDepartment of Physiology and Cell Biology, The Ohio State University, Columbus, Ohio, USA.
Paul T MartinCenter for Gene Therapy, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA Paul.Martin@nationwidechildrens.org.
Nationwide Children's Hospital · USThe Ohio State University · USBaylor College of Medicine · USCenter for Human Genetics · USHamad bin Khalifa University · QAUniversity of Michigan–Ann Arbor · US

Funding

Glycosyltransferase Therapy for MyopathiesR01AR049722 · NIAMS · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI MARTIN, PAUL TAYLOR · 2006 to 2018
$4.2M
Training in neuromuscular diseasesT32NS077984 · NINDS · OHIO STATE UNIVERSITY · PI GUTTRIDGE, DENIS C, MENDELL, JERRY ROY · 2012 to 2016
$946k
A myoutube-specific deletion model for sarcopeniaR21AR060412 · NIAMS · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI MARTIN, PAUL TAYLOR · 2012 to 2013
$350k
NIAMS NIH HHS R01 AR049722NIAMS NIH HHS R21 AR060412NINDS NIH HHS T32 NS077984
6 · The paper itself

Abstract

Sarcopenia, the loss of muscle mass and strength during normal aging, involves coordinate changes in skeletal myofibers and the cells that contact them, including satellite cells and motor neurons. Here we show that the protein

Indexed as

AgingAnimalsCell Cycle ProteinsCells, CulturedFemaleFucosyltransferasesGene Expression ProfilingGene Expression RegulationMaleMiceMice, Inbred C57BLMotor NeuronsMuscle Fibers, SkeletalNeuromuscular JunctionPhenotypeReceptors, NotchCell Cycle ProteinsFucosyltransferasesPofut1 protein, mouseReceptors, Notchglycobiologymuscle agingNotch signalingsarcopenia

Identifiers

PMID28265002
PMCPMC5477548
OpenAlexW2591688689

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.