Evidence map›Paper›PMID 28264852›Full record

ArticleAntimicrobial agents and chemotherapy2017

Paritaprevir and Ritonavir Liver Concentrations in Rats as Assessed by Different Liver Sampling Techniques.

Charles S Venuto, Marianthi Markatou, Yvonne Woolwine-Cunningham, Rosemary Furlage, Andrew J Ocque, Robin DiFrancesco, Emily O Dumas, Paul K Wallace, Gene D Morse, Andrew H Talal

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Trial
  2. Article
  3. Hepatic Transcript Profiles of Cytochrome P450 Genes Predict Sex Differences in Drug Metabolism.Drug metabolism and disposition: the biological fate of chemicals · 2020
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Charles S VenutoDepartment of Neurology, Center for Human Experimental Therapeutics, University of Rochester, Rochester, New York, USA.
Marianthi MarkatouDepartment of Biostatistics, University at Buffalo, Buffalo, New York, USA.
Yvonne Woolwine-CunninghamDivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University at Buffalo, Buffalo, New York, USA.
Rosemary FurlageDepartment of Flow & Image Cytometry, Roswell Park Cancer Institute, Buffalo, New York, USA.
Andrew J OcqueAIDS Clinical Trials Group Pharmacology Specialty Laboratory, New York State Center of Excellence in Bioinformatics and Life Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, New York, USA.
Robin DiFrancescoAIDS Clinical Trials Group Pharmacology Specialty Laboratory, New York State Center of Excellence in Bioinformatics and Life Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, New York, USA.
Emily O DumasAbbVie Inc., North Chicago, Illinois, USA.
Paul K WallaceDepartment of Flow & Image Cytometry, Roswell Park Cancer Institute, Buffalo, New York, USA.
Gene D MorseAIDS Clinical Trials Group Pharmacology Specialty Laboratory, New York State Center of Excellence in Bioinformatics and Life Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, New York, USA.
Andrew H TalalDivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University at Buffalo, Buffalo, New York, USA ahtalal@buffalo.edu.
AIDS Clinical Trials Group · USUniversity at Buffalo, State University of New York · USRoswell Park Comprehensive Cancer Center · USAbbVie (United States) · USUniversity of Rochester · US

Funding

Validation, CLIA and Qualification (VQC): Enhancing the RS ratio as a tool for AIDS Clinical Trial Group (ACTG) tuberculosis trialsUM1AI106701 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Grace M Aldrovandi · 2014 to 2026
$116.8M
Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI Dean G. Tang · 1985 to 2026
$116.6M
University of Buffalo Clinical and Translational Science Institute - Supplement SchulyerUL1TR001412 · NCATS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI MURPHY, TIMOTHY F · 2015 to 2024
$33.8M
Quantitative Pharmacology for Accelerating Drug Development for HIV/HCV Co-Infected PatientsK23AI108355 · NIAID · UNIVERSITY OF ROCHESTER · PI VENUTO, CHARLES STANLEY · 2015 to 2019
$720k
NCATS NIH HHS UL1 TR001412NCI NIH HHS P30 CA016056NIAID NIH HHS K23 AI108355NIAID NIH HHS UM1 AI106701
6 · The paper itself

Abstract

The liver is crucial to pharmacology, yet substantial knowledge gaps exist in the understanding of its basic pharmacologic processes. An improved understanding for humans requires reliable and reproducible liver sampling methods. We compared liver concentrations of paritaprevir and ritonavir in rats by using samples collected by fine-needle aspiration (FNA), core needle biopsy (CNB), and surgical resection. Thirteen Sprague-Dawley rats were evaluated, nine of which received paritaprevir/ritonavir at 30/20 mg/kg of body weight by oral gavage daily for 4 or 5 days. Drug concentrations were measured using liquid chromatography-tandem mass spectrometry on samples collected via FNA (21G needle) with 1, 3, or 5 passes (FNA

Indexed as

AnimalsBiopsy, Fine-NeedleChromatography, LiquidCyclopropanesHepatocytesInactivation, MetabolicLactams, MacrocyclicLiverMacrocyclic CompoundsMaleProlineRatsRats, Sprague-DawleyRitonavirSulfonamidesTandem Mass SpectrometryCyclopropanesLactams, MacrocyclicMacrocyclic CompoundsparitaprevirProlineRitonavirSulfonamideshepatocyte isolationliver biopsyliver drug concentrationliver fine-needle aspiration

Identifiers

PMID28264852
PMCPMC5404580
OpenAlexW2592425993

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.