Evidence map›Paper›PMID 28264842›Full record

ArticleAntimicrobial agents and chemotherapy2017

Contributions of both ATP-Binding Cassette Transporter and Cyp51A Proteins Are Essential for Azole Resistance in Aspergillus fumigatus.

Sanjoy Paul, Daniel Diekema, W Scott Moye-Rowley

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 63 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Understanding multi-azole resistance inFrontiers in fungal biology · 2026
    Article
  5. DisseminatedFrontiers in medicine · 2026
    Article
  6. Multidrug efflux pumps and innate azole resistance of Mucor lusitanicus.The Journal of antimicrobial chemotherapy · 2025
    Article
  7. Article
  8. Azole-ResistantJournal of fungi (Basel, Switzerland) · 2025
    Review
  9. Article
  10. Review
  11. Mycology · 2025
    Article
  12. Article
  13. Loss of a conserved C-terminal region of thebioRxiv : the preprint server for biology · 2024
    Article
  14. Drug-ResistantPathogens (Basel, Switzerland) · 2023
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Sanjoy PaulDepartment of Molecular Physiology and Biophysics, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Daniel DiekemaDepartment of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
W Scott Moye-RowleyDepartment of Molecular Physiology and Biophysics, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA scott-moye-rowley@uiowa.edu.
University of Iowa · US

Funding

GENETIC ANALYSIS OF PLEIOTROPIC DRUG RESISTANCER01GM049825 · NIGMS · UNIVERSITY OF IOWA · PI MOYE-ROWLEY, W SCOTT · 1993 to 2019
$6.0M
A new pathway for azole resistance in Aspergillus fumigatusR21AI113748 · NIAID · UNIVERSITY OF IOWA · PI MOYE-ROWLEY, W SCOTT · 2015 to 2016
$404k
NIAID NIH HHS R21 AI113748NIGMS NIH HHS R01 GM049825
6 · The paper itself

Abstract

While azole drugs targeting the biosynthesis of ergosterol are effective antifungal agents, their extensive use has led to the development of resistant organisms. Infections involving azole-resistant forms of the filamentous fungus

Indexed as

Antifungal AgentsAspergillosisAspergillus fumigatusATP Binding Cassette Transporter, Subfamily G, Member 1AzolesCytochrome P-450 Enzyme SystemDrug Resistance, FungalFungal ProteinsGene DeletionMicrobial Sensitivity TestsPromoter Regions, GeneticVoriconazoleAntifungal AgentsATP Binding Cassette Transporter, Subfamily G, Member 1Azolescytochrome P-450 CYP51A, AspergillusCytochrome P-450 Enzyme SystemFungal ProteinsVoriconazoleAspergillus fumigatusATP-binding cassette transporterazole resistancecyp51Agenetic analysisWestern blotting

Identifiers

PMID28264842
PMCPMC5404575
OpenAlexW2591993183

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.