Evidence map›Paper›PMID 28264838›Full record

ArticleCancer prevention research (Philadelphia, Pa.)2017

Loss of BRCA1 in the Cells of Origin of Ovarian Cancer Induces Glycolysis: A Window of Opportunity for Ovarian Cancer Chemoprevention.

Tatsuyuki Chiyoda, Peter C Hart, Mark A Eckert, Stephanie M McGregor, Ricardo R Lastra, Ryuji Hamamoto, Yusuke Nakamura, S Diane Yamada, Olufunmilayo I Olopade, Ernst Lengyel and 1 more

Open access · greenAbstract read
In one paragraph

Article in Cancer prevention research (Philadelphia, Pa.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 32 citations in OpenAlex.

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  16. Plasma Metabolome Signature Indicative ofFrontiers in oncology · 2021
    Article
  17. Review
  18. Genome-Protecting Compounds as Potential Geroprotectors.International journal of molecular sciences · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Tatsuyuki ChiyodaDepartment of Obstetrics and Gynecology/Section of Gynecologic Oncology, The University of Chicago, Chicago, Illinois.
Peter C HartDepartment of Obstetrics and Gynecology/Section of Gynecologic Oncology, The University of Chicago, Chicago, Illinois.
Mark A EckertDepartment of Obstetrics and Gynecology/Section of Gynecologic Oncology, The University of Chicago, Chicago, Illinois.
Stephanie M McGregorDepartment of Pathology, The University of Chicago, Chicago, Illinois.
Ricardo R LastraDepartment of Pathology, The University of Chicago, Chicago, Illinois.
Ryuji HamamotoDepartment of Medicine, Section of Hematology/Oncology, The University of Chicago, Chicago, Illinois.
Yusuke NakamuraDepartment of Medicine, Section of Hematology/Oncology, The University of Chicago, Chicago, Illinois.
S Diane YamadaDepartment of Obstetrics and Gynecology/Section of Gynecologic Oncology, The University of Chicago, Chicago, Illinois.
Olufunmilayo I OlopadeDepartment of Medicine, Section of Hematology/Oncology, The University of Chicago, Chicago, Illinois.
Ernst LengyelDepartment of Obstetrics and Gynecology/Section of Gynecologic Oncology, The University of Chicago, Chicago, Illinois.
Iris L RomeroDepartment of Obstetrics and Gynecology/Section of Gynecologic Oncology, The University of Chicago, Chicago, Illinois. iromero@babies.bsd.uchicago.edu.
University of Chicago · US

Funding

VIRAL ONCOLOGY CORE FACILITYP30CA014599 · NCI · UNIVERSITY OF CHICAGO · PI MARK W. LINGEN · 1985 to 2026
$122.1M
Use of microfluidic tumor cultures to enable clinical trials of therapies for ovarian cancerP50CA136393 · NCI · MAYO CLINIC ROCHESTER · PI Zhenkun Lou · 2009 to 2026
$37.0M
REPRODUCTIVE SCIENTIST TRAINING PROGRAMK12HD000849 · NICHD · WASHINGTON UNIVERSITY · PI Danny J Schust · 1988 to 2026
$33.2M
Regulation of Adhesion and Proteolysis in Ovarian CancerR01CA111882 · NCI · UNIVERSITY OF CHICAGO · PI LENGYEL, ERNST · 2006 to 2016
$2.8M
Metabolic changes in ovarian cancer cells initiated by metastasis to adipose tissR01CA169604 · NCI · UNIVERSITY OF CHICAGO · PI LENGYEL, ERNST · 2013 to 2017
$1.7M
NCI NIH HHS L30 CA153336NCI NIH HHS P30 CA014599NCI NIH HHS P50 CA136393NCI NIH HHS R01 CA111882NCI NIH HHS R01 CA169604NICHD NIH HHS K12 HD000849
6 · The paper itself

Abstract

Mutations in the breast cancer susceptibility gene 1 (

Indexed as

GlycolysisAspirinBRCA1 ProteinCarcinoma, Ovarian EpithelialCell Line, TumorChemopreventionCyclooxygenase 2 InhibitorsEpithelial CellsFallopian TubesFemaleHumansMutationNeoplasms, Glandular and EpithelialOvarian NeoplasmsAspirinBRCA1 ProteinBRCA1 protein, humanCyclooxygenase 2 Inhibitors

Identifiers

PMID28264838
PMCPMC5425093
OpenAlexW2592082118

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.