Trial reportBMJ open2017
Changing trends in reproductive/lifestyle factors in UK women: descriptive study within the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS).
Trial report in BMJ open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Association between skirt size and chronic liver disease in post-menopausal women: a prospective cohort study within the United Kingdom Trial of Ovarian Cancer Screening (UKCTOCS).BMC public health · 2018Trial
- Reproductive Risk Factor Patterns in Caribbean Women With Breast Cancer Across 4 Generations.JAMA network open · 2024Observational
- Tubal Cancer Clinical Management: Two Exceptional Scenarios and a Review of the Literature.Journal of clinical medicine · 2024Review
- [Secular trends of age at menarche and age at menopause in women born since 1951 from a county of Shandong Province, China].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2023Article
- Identifying potential causal effects of age at menopause: a Mendelian randomization phenome-wide association study.European journal of epidemiology · 2022Article
- Temporal trends in age at menarche and age at menopause: a population study of 312 656 women in Norway.Human reproduction (Oxford, England) · 2020Article
- The Association Between Hysterectomy and Ovarian Cancer Risk: A Population-Based Record-Linkage Study.Journal of the National Cancer Institute · 2019Article
- Observational
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 4 countries.
Funding
Abstract
objectiveThere has been considerable interest in the impact of reproductive factors on health but there are little data on how these have varied over time. We explore trends in reproductive/lifestyle factors of postmenopausal British women by analysing self-reported data from participants of the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS).
designProspective birth cohort analysis.
settingPopulation cohort invited between 2001 and 2005 from age-sex registers of 27 Primary Care Trusts in England, Wales and Northern Ireland and recruited through 13 National Health Service Trusts.
participants202 638 postmenopausal women aged 50-74 years at randomisation to UKCTOCS between April 2001 and October 2005.
interventionsWomen were stratified into the following six birth cohorts (1925-1929, 1930-1934, 1935-1939, 1940-1944, 1945-1949, 1950-1955) based on year of birth. Self-reported data on reproductive factors provided at recruitment were explored using tabular and graphical summaries to examine for differences between the birth cohorts. OUTCOME MEASURES: Trends in mean age at menarche and menopause, use of oral contraceptives, change in family size, infertility treatments, tubal ligation and hysterectomy rates.
resultsWomen born between 1935 and 1955 made up 86% of the cohort. Median age at menarche decreased from 13.4 for women born between 1925 and 1929 to 12.8 for women born between 1950 and 1955. Increased use of the oral contraceptives, infertility treatments and smaller family size was observed in the younger birth cohorts. Tubal ligation rates increased for those born between 1925 and 1945, but this increase did not persist in subsequent cohorts. Hysterectomy rates (17-20%) did not change over time.
conclusionsThe trends seen in this large cohort are likely to reflect the reproductive history of the UK female postmenopausal population of similar age. Since these are risk factors for hormone-related cancers, these trends are important in understanding the changing incidence of these cancers. TRIAL REGISTRATION NUMBER: International Standard Randomised Controlled Trial Number: 22488978.
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