ReviewCold Spring Harbor perspectives in biology2018
Role of Polarity Proteins in the Generation and Organization of Apical Surface Protrusions.
Review in Cold Spring Harbor perspectives in biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Optimized primary organotypic culture from murine neonatal tracheal airway epithelial cells.American journal of physiology. Lung cellular and molecular physiology · 2026Article
- Endothelial-specific genes TMTC1, RPS6KA2, and F8 are downregulated in hypertrophic cardiomyopathy.European journal of medical research · 2025Article
- Soma-germ contact across the basement membrane in the ovary.Biology letters · 2025Article
- Actin-templated Structures: Nature's Way to Hierarchical Surface Patterns (Gecko's Setae as Case Study).Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Identification of a novelFrontiers in pediatrics · 2024Article
- A deep learning framework for quantitative analysis of actin microridges.NPJ systems biology and applications · 2023Article
- Dysregulation of polarity proteins in astrocyte reactivity.Ageing research reviews · 2023Article
- The role of polarization and early heterogeneities in the mammalian first cell fate decision.Current topics in developmental biology · 2023Review
- Role of Spectrin in Endocytosis.Cells · 2022Review
- New mouse models for high resolution and live imaging of planar cell polarity proteins in vivo.Development (Cambridge, England) · 2021Article
- Hydroxylated sphingolipid biosynthesis regulates photoreceptor apical domain morphogenesis.The Journal of cell biology · 2020Article
- The Urothelium: Life in a Liquid Environment.Physiological reviews · 2020Review
- Cell Polarity Protein Pals1-Associated Tight Junction Expression Is a Favorable Prognostic Marker in Clear Cell Renal Cell Carcinoma.Frontiers in genetics · 2020Article
- Regulation of the apical extension morphogenesis tunes the mechanosensory response of microvilliated neurons.PLoS biology · 2019Article
- Development and Clinical Validation of a Seven-Gene Prognostic Signature Based on Multiple Machine Learning Algorithms in Kidney Cancer.Cell transplantationArticle
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Protruding from the apical surfaces of epithelial cells are specialized structures, including cilia, microplicae, microvilli, and stereocilia. These contribute to epithelial function by cushioning the apical surface, by amplifying its surface area to facilitate nutrient absorption, and by promoting sensory transduction and barrier function. Despite these important roles, and the diseases that result when their formation is perturbed, there remain significant gaps in our understanding of the biogenesis of apical protrusions, or the pathways that promote their organization and orientation once at the apical surface. Here, I review some general aspects of these apical structures, and then discuss our current understanding of their formation and organization with respect to proteins that specify apicobasolateral polarity and planar cell polarity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.