ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2017
Clinical and genetic analyses of familial and sporadic frontotemporal dementia patients in Southern Italy.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 35 citations in OpenAlex.
- Genetics of Frontotemporal Dementia in the Serbian Population: Findings from a Hospital-Based Cohort.Neurology international · 2025Article
- Letter to the Editor Response to: Is Transcranial Direct Current Stimulation Really Beneficial for Frontotemporal Dementia? (Published 12-18-2024).Journal of central nervous system disease · 2025Article
- Diagnostic accuracy of research criteria for prodromal frontotemporal dementia.Alzheimer's research & therapy · 2024Article
- Antemortem network analysis of spreading pathology in autopsy-confirmed frontotemporal degeneration.Brain communications · 2023Article
- Neurocognitive patterns across genetic levels in behavioral variant frontotemporal dementia: a multiple single cases study.BMC neurology · 2022Article
- Phases of volume loss in patients with known frontotemporal lobar degeneration spectrum pathology.Neurobiology of aging · 2022Article
- Differences and similarities between familial and sporadic frontotemporal dementia: An Italian single-center cohort study.Alzheimer's & dementia (New York, N. Y.) · 2022Article
- Regenerative Stem Cell Therapy for Neurodegenerative Diseases: An Overview.International journal of molecular sciences · 2021Review
- Transcriptomic and Network Meta-Analysis of Frontotemporal Dementias.Frontiers in molecular neuroscience · 2021Article
- Development of disease-modifying drugs for frontotemporal dementia spectrum disorders.Nature reviews. Neurology · 2020Review
- Comparison of sporadic and familial behavioral variant frontotemporal dementia (FTD) in a North American cohort.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2020Article
- Heritability in frontotemporal tauopathies.Alzheimer's & dementia (Amsterdam, Netherlands) · 2019Article
- The Missing Heritability of Sporadic Frontotemporal Dementia: New Insights from Rare Variants in Neurodegenerative Candidate Genes.International journal of molecular sciences · 2019Article
- Frontotemporal dementia: latest evidence and clinical implications.Therapeutic advances in psychopharmacology · 2018Review
- Letter.Alzheimer's & dementia (Amsterdam, Netherlands) · 2017Article
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Authors and funding
19 authors at 9 institutions in 3 countries.
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Abstract
introductionWe investigated the clinical differences between familial and sporadic frontotemporal dementia (FTD), screening for mutations in known FTD genes.
methodsWe diagnosed 22 affected individuals belonging to eight families and 43 sporadic cases with FTD in Apulia, Southern Italy, in 2 years. Mutations in common causative FTD genes (GRN, MAPT, VCP, and TARDBP) and C9ORF72 expansions were screened.
resultsBehavioral variant of FTD was the most common clinical subtype (50% and 69% in familial and sporadic cases, respectively). Social conduct impairment/disinhibition, loss of insight, and inflexibility were the most frequent clinical features observed at onset. One new mutation was identified in GRN in family A. DISCUSSION: Disease onset in sporadic FTD was more frequently characterized by a clustering of behavioral symptoms with apathy and loss of personal hygiene. Mutations in common causative FTD genes are not a major cause of familial and sporadic FTD in the Southern Italian population.
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