ArticleBMC pregnancy and childbirth2017
Validation of serum progesterone <35nmol/L as a predictor of miscarriage among women with threatened miscarriage.
Article in BMC pregnancy and childbirth, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Can single progesterone concentration predict miscarriage in early pregnant women with threatened miscarriage: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2024Pooled it
- Pooled it
- A multivariable risk prediction model for pregnancies of uncertain viability without a fetal pole: a prospective cohort study.Frontiers in medicine · 2026Article
- Vaginal Bleeding After Pregnancy: Progesterone Levels and Pregnancy Outcomes in the First Trimester.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2025Article
- Prediction of Pregnancy Outcomes in Women with Threatened Abortion Using Ultrasound Parameters, Uterine Artery Doppler, and Serum Progesterone Levels: A Prospective Cohort Study.Journal of obstetrics and gynaecology of India · 2025Article
- Weekly changes in serumThe Journal of international medical research · 2025Article
- Does Corpus Luteum Doppler Have a Role in Prognostic Prediction for Outcome with Threatened Abortion?Journal of clinical medicine · 2025Article
- Progesterone decline threshold in predicting early pregnancy loss: a retrospective study.Frontiers in endocrinology · 2025Article
- Untargeted metabolomics reveals key pathways in miscarriage: steroid, folate, fatty acid & glycosaminoglycan metabolism.npj women's health · 2025Article
- A risk prediction model of spontaneous miscarriage in women with threatened miscarriage: a prospective cohort study.Frontiers in medicine · 2025Article
- Progesterone in frozen embryo transfer cycles: assays, circulating concentrations, metabolites, and molecular action.F&S reports · 2024Article
- The predictive value of ultrasound markers for pregnancy outcomes in recurrent pregnancy loss: a retrospective study.Scientific reports · 2024Article
- Diabetes Mellitus and Gynecological and Inflammation Disorders Increased the Risk of Pregnancy Loss in a Population Study.Life (Basel, Switzerland) · 2024Article
- Exploring Progesterone Deficiency in First-Trimester Miscarriage and the Impact of Hormone Therapy on Foetal Development: A Scoping Review.Children (Basel, Switzerland) · 2024Article
- Prediction of miscarriage in first trimester by serum estradiol, progesterone and β-human chorionic gonadotropin within 9 weeks of gestation.BMC pregnancy and childbirth · 2022Article
- Article
- Luteal phase deficiency during the early trimester in a case with secondary hypopituitarism following craniopharyngioma resection.The journal of obstetrics and gynaecology research · 2021Article
- Gestational age-specific normative values and determinants of serum progesterone through the first trimester of pregnancy.Scientific reports · 2021Article
- The Clinical Value of 3D Ultrasonic Measurement of the Ratio of Gestational Sac Volume to Embryo Volume in IoT-Based Prediction of Pregnancy Outcome.Journal of healthcare engineering · 2021Observational
- Novel approach using serum progesterone as a triage to guide management of patients with threatened miscarriage: a prospective cohort study.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOur recent paper, based on a pilot cohort of 119 women, showed that serum progesterone <35 nmol/L was prognostic of spontaneous miscarriage by 16 weeks in women with threatened miscarriage in early pregnancy. Using a larger cohort of women from the same setting (validation cohort), we aim to assess the validity of serum progesterone <35 nmol/L with the outcome of spontaneous miscarriage by 16 weeks.
methodsIn a prospective cohort study, 360 pregnant women presenting with threatened miscarriage between gestation weeks 6-10 at a tertiary hospital emergency unit for women in Singapore were recruited for this study. The main outcome measure measured is spontaneous miscarriage prior to week 16 of gestation. Area under the ROC curve (AUC) and test characteristics (sensitivity, specificity, positive and negative predictive value) at a serum progesterone cutpoint of <35 nmol/L for predicting high and low risk of spontaneous miscarriage by 16 weeks were compared between the Pilot and Validation cohorts.
resultsTest characteristics and AUC values using serum progesterone <35 nmol/L in the validation cohort were not significantly different from those in the Pilot cohort, demonstrating excellent accuracy and reproducibility of the proposed serum progesterone cut-off level.
conclusionsThe cut-off value for serum progesterone (35 nmol/L) demonstrated clinical relevance and allow clinicians to stratify patients into high and low risk groups for spontaneous miscarriage.
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