ArticleACS synthetic biology2017
Quantitative Analysis of Synthetic Cell Lineage Tracing Using Nuclease Barcoding.
Article in ACS synthetic biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed.
- Direct and indirect neurogenesis from radial glial progenitor cell clones in the mouse neocortex.The EMBO journal · 2026Article
- Barcodes based on nucleic acid sequences: Applications and challenges (Review).Molecular medicine reports · 2025Review
- Advances in CRISPR-Cas9 in lineage tracing of model animals.Animal models and experimental medicine · 2025Review
- LINNAEUS: Simultaneous Single-Cell Lineage Tracing and Cell Type Identification.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Genetic Tools for Cell Lineage Tracing and Profiling Developmental Trajectories in the Skin.The Journal of investigative dermatology · 2024Review
- LinRace: cell division history reconstruction of single cells using paired lineage barcode and gene expression data.Nature communications · 2023Article
- A New Generation of Lineage Tracing Dynamically Records Cell Fate Choices.International journal of molecular sciences · 2022Review
- Determining lineage relationships in kidney development and disease.Nature reviews. Nephrology · 2022Review
- A topological look into the evolution of developmental programs.Biophysical journal · 2021Article
- Retrospective cell lineage reconstruction in humans by using short tandem repeats.Cell reports methods · 2021Article
- ESTIMATION OF CELL LINEAGE TREES BY MAXIMUM-LIKELIHOOD PHYLOGENETICS.The annals of applied statistics · 2021Article
- Single-Cell Transcriptomic Analysis of Cardiac Progenitor Differentiation.Current cardiology reports · 2020Review
- Identification of Neuronal Lineages in the Drosophila Peripheral Nervous System with a "Digital" Multi-spectral Lineage Tracing System.Cell reports · 2019Article
- Nucleic acid cleavage with a hyperthermophilic Cas9 from an uncultured Ignavibacterium.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Recording development with single cell dynamic lineage tracing.Development (Cambridge, England) · 2019Review
- Integrative single-cell analysis.Nature reviews. Genetics · 2019Review
- Lineage tracing using a Cas9-deaminase barcoding system targeting endogenous L1 elements.Nature communications · 2019Article
- Maps of variability in cell lineage trees.PLoS computational biology · 2019Article
- Article
- Expanding the CRISPR Toolbox in Zebrafish for Studying Development and Disease.Frontiers in cell and developmental biology · 2019Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Lineage tracing by the determination and mapping of progeny arising from single cells is an important approach enabling the elucidation of mechanisms underlying diverse biological processes ranging from development to disease. We developed a dynamic sequence-based barcode system for synthetic lineage tracing and have demonstrated its performance in C. elegans, a model organism whose lineage tree is well established. The strategy we use creates lineage trees based upon the introduction of synthetically controlled mutations into cells and the propagation of these mutations to daughter cells at each cell division. We analyzed this experimental proof of concept along with a corresponding simulation and analytical model to gain a deeper understanding of the coding capacity of the system. Our results provide specific bounds on the fidelity of lineage tracing using such approaches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.