Evidence map›Paper›PMID 28264501›Full record

ArticleNutrients2017

Anticancer and Anti-Inflammatory Properties of Ganoderma lucidum Extract Effects on Melanoma and Triple-Negative Breast Cancer Treatment.

Antonio Barbieri, Vincenzo Quagliariello, Vitale Del Vecchio, Michela Falco, Antonio Luciano, Nagoth Joseph Amruthraj, Guglielmo Nasti, Alessandro Ottaiano, Massimiliano Berretta, Rosario Vincenzo Iaffaioli and 1 more

Registry-linked trialAbstract read
In one paragraph

Article in Nutrients, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04821258 (Double-blind Randomized Clinical Trial to Evaluate the Effect of the Nutraceutical "MICODIGEST 2.0" on the Complications After Surgery With Curative Intent for Colorectal Cancer), which is not on this map. Cited by 60 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04821258 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Double-blind Randomized Clinical Trial to Evaluate the Effect of the Nutraceutical "MICODIGEST 2.0" on the Complications After Surgery With Curative Intent for Colorectal Cancer

TypeinterventionalSponsorFundacin Biomedica Galicia SurRan2021 to 2022Enrolled144ConditionsColorectal Cancer, Surgery--ComplicationsArmsMICODIGEST 2.0 supplement, Placebo supplement
3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Use ofNutrients · 2020
    Pooled it
  3. Cadmium inhibits hSMUG1-mediated uracil excision: quantitative analysis and mitigation byJournal of enzyme inhibition and medicinal chemistry · 2026
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  9. Journal of Cancer · 2026
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  10. Evaluation of Anticancer Potential ofAntioxidants (Basel, Switzerland) · 2025
    Article
  11. Effect ofFood science & nutrition · 2025
    Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Unlocking the Potential ofPharmaceutics · 2025
    Review
  17. Survival Benefits ofRecent patents on anti-cancer drug discovery · 2025
    Article
  18. Article
  19. Evaluation ofFrontiers in pharmacology · 2025
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Antonio BarbieriAnimal Facility Unit, Department of Research, National Cancer Institute "G. Pascale", Via M. Semmola, 80131 Naples, Italy. a.barbieri@istitutotumori.na.it.
Vincenzo QuagliarielloDepartment of Abdominal Oncology, National Cancer Institute "G. Pascale", Via M. Semmola, 80131 Naples, Italy. quagliariello.enzo@gmail.com.
Vitale Del VecchioAnimal Facility Unit, Department of Research, National Cancer Institute "G. Pascale", Via M. Semmola, 80131 Naples, Italy. vitale_84@hotmail.it.
Michela FalcoAnimal Facility Unit, Department of Research, National Cancer Institute "G. Pascale", Via M. Semmola, 80131 Naples, Italy. michelafalco_89@libero.it.
Antonio LucianoAnimal Facility Unit, Department of Research, National Cancer Institute "G. Pascale", Via M. Semmola, 80131 Naples, Italy. a.luciano@istitutotumori.na.it.
Nagoth Joseph AmruthrajClinical, Experimental and Medical Sciences, Chair of Nephrology, Department of Cardio-Vascular Medicine, University of Study of Campania "Luigi Vanvitelli", 81100 Caserta, Italy. amruthjon@gmail.com.
Guglielmo NastiDepartment of Abdominal Oncology, National Cancer Institute "G. Pascale", Via M. Semmola, 80131 Naples, Italy. guglielmo.nasti@libero.it.
Alessandro OttaianoDepartment of Abdominal Oncology, National Cancer Institute "G. Pascale", Via M. Semmola, 80131 Naples, Italy. ale.otto@libero.it.
Massimiliano BerrettaASMO (Association for Multidisciplinary Studies in Oncology) and Mediterranean Diet, Piazza Nicola Amore 6, 80138 Naples, Italy. mberretta@cro.it.
Rosario Vincenzo IaffaioliDepartment of Abdominal Oncology, National Cancer Institute "G. Pascale", Via M. Semmola, 80131 Naples, Italy. rv.iaffaioli@gmail.com.
Claudio ArraAnimal Facility Unit, Department of Research, National Cancer Institute "G. Pascale", Via M. Semmola, 80131 Naples, Italy. c.arra@istitutotumori.na.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Among the most important traditional medicinal fungi,

Indexed as

AnimalsAnti-Inflammatory AgentsAntineoplastic AgentsCell Line, TumorCell ProliferationHumansInterleukin-6Interleukin-8Matrix Metalloproteinase 2Matrix Metalloproteinase 9MelanomaMiceMice, Inbred C57BLReishiTriple Negative Breast NeoplasmsAnti-Inflammatory AgentsAntineoplastic AgentsInterleukin-6Interleukin-8Matrix Metalloproteinase 2Matrix Metalloproteinase 9breast cancercell viabilitycurcumincytokinesGanoderma luciduminflammationmelanoma

Identifiers

PMID28264501
PMCPMC5372873

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.