ArticleJAMA neurology2017
Association Between Migraine and Cervical Artery Dissection: The Italian Project on Stroke in Young Adults.
Article in JAMA neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 7 of them syntheses that pooled it.
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Who cites it
37 citing papers in PubMed, 7 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- Risk factors for cervical artery dissection: a systematic review with meta-analysis.Stroke and vascular neurology · 2026Pooled it
- Migraine and pregnancy-related headaches as a risk factor for cardiovascular and cerebrovascular events in pregnancy: a systematic review and meta-analysis of over 94 million pregnancies.The journal of headache and pain · 2025Pooled it
- Genetically proxied liability to migraine and risk of intracranial aneurysm and subarachnoid hemorrhage.Headache · 2025Pooled it
- Migraine and the risk of cervical artery dissection: A systematic review and meta-analysis.European stroke journal · 2023Pooled it
- Association between migraine and risk of stroke: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Pooled it
- Headache in cervicocerebral artery dissection.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Pooled it
- The Impact of Spinal Manipulation on Migraine Pain and Disability: A Systematic Review and Meta-Analysis.Headache · 2019Pooled it
- Fibromuscular Dysplasia and Spontaneous Cervical Artery Dissection.JAMA network open · 2025Article
- Migraine and stroke: correlation, coexistence, dependence - a modern perspective.The journal of headache and pain · 2025Review
- Clinical Characteristics of Ischemic Stroke in Japanese Young Adults.Cerebrovascular diseases extra · 2025Article
- Novel Calcitonin Gene-Related Peptide (CGRP) Interfering Migraine Therapies and Stroke-A Review.International journal of molecular sciences · 2024Review
- Association between vertebral artery dominance and basilar artery curvature in migraineurs: an anatomical magnetic resonance imaging study.The neuroradiology journal · 2024Article
- Cervical Artery Dissections-A Demographical Analysis of Risk Factors, Clinical Characteristics Treatment Procedures, and Outcomes-A Single Centre Study of 54 Consecutive Cases.Journal of personalized medicine · 2023Article
- Susceptibility to brain ischemia and the association between migraine and spontaneous cervical artery dissection.Journal of neurology · 2023Article
- Secondary headaches - red and green flags and their significance for diagnostics.eNeurologicalSci · 2023Review
- Advances in Management of the Stroke Etiology One-Percenters.Current neurology and neuroscience reports · 2023Review
- Microembolism and Other Links Between Migraine and Stroke: Clinical and Pathophysiologic Update.Neurology · 2023Review
- Cardiovascular Risk Factors and Family History of Major Thrombotic Events in Children with Migraine: A 12-Year Retrospective Single-Centre Study.Journal of clinical medicine · 2023Article
- Diagnostic potential of routine brain MRI and high-resolution, multi-contrast vessel wall imaging in the detection of internal carotid artery dissection.Frontiers in neurology · 2023Article
- Clinical criteria to exclude acute vascular pathology on CT angiogram in patients with dizziness.PloS one · 2023Article
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Authors and funding
57 authors at 20 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Importance: Although sparse observational studies have suggested a link between migraine and cervical artery dissection (CEAD), any association between the 2 disorders is still unconfirmed. This lack of a definitive conclusion might have implications in understanding the pathogenesis of both conditions and the complex relationship between migraine and ischemic stroke (IS). Objective: To investigate whether a history of migraine and its subtypes is associated with the occurrence of CEAD. Design, Setting, and Participants: A prospective cohort study of consecutive patients aged 18 to 45 years with first-ever acute ischemic stroke enrolled in the multicenter Italian Project on Stroke in Young Adults was conducted between January 1, 2000, and June 30, 2015. In a case-control design, the study assessed whether the frequency of migraine and its subtypes (presence or absence of an aura) differs between patients whose IS was due to CEAD (CEAD IS) and those whose IS was due to a cause other than CEAD (non-CEAD IS) and compared the characteristics of patients with CEAD IS with and without migraine. Main Outcomes and Measures: Frequency of migraine and its subtypes in patients with CEAD IS vs non-CEAD IS. Results: Of the 2485 patients (mean [SD] age, 36.8 [7.1] years; women, 1163 [46.8%]) included in the registry, 334 (13.4%) had CEAD IS and 2151 (86.6%) had non-CEAD IS. Migraine was more common in the CEAD IS group (103 [30.8%] vs 525 [24.4%], P = .01), and the difference was mainly due to migraine without aura (80 [24.0%] vs 335 [15.6%], P < .001). Compared with migraine with aura, migraine without aura was independently associated with CEAD IS (OR, 1.74; 95% CI, 1.30-2.33). The strength of this association was higher in men (OR, 1.99; 95% CI, 1.31-3.04) and in patients 39.0 years or younger (OR, 1.82; 95% CI, 1.22-2.71). The risk factor profile was similar in migrainous and non-migrainous patients with CEAD IS (eg, hypertension, 20 [19.4%] vs 57 [24.7%], P = .29; diabetes, 1 [1.0%] vs 3 [1.3%], P > .99). Conclusions and Relevance: In patients with IS aged 18 to 45 years, migraine, especially migraine without aura, is consistently associated with CEAD. This finding suggests common features and warrants further analyses to elucidate the underlying biologic mechanisms.
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