Evidence map›Paper›PMID 28264045›Full record

ArticlePloS one2017

ART attrition and risk factors among Option B+ patients in Haiti: A retrospective cohort study.

Nancy Puttkammer, Jean Wysler Domerçant, Michelle Adler, Krista Yuhas, Martine Myrtil, Paul Young, Kesner François, Reynold Grand'Pierre, David Lowrance

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Nancy PuttkammerInternational Training and Education Center for Health (I-TECH), Department of Global Health, University of Washington, Seattle, Washington, United States of America.ORCID http://orcid.org/0000-0002-6693-9278
Jean Wysler DomerçantUS Centers for Disease Control and Prevention, Port au Prince, Haiti.
Michelle AdlerUS Centers for Disease Control and Prevention, Kampala, Uganda.
Krista YuhasCenter for AIDS Research, University of Washington, Seattle, Washington, United States of America.
Martine MyrtilDepartment of Global Health, University of Washington, Seattle, Washington, United States of America.
Paul YoungUS Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America.
Kesner FrançoisMinistry of Public Health and Population, Government of Haiti, Port au Prince, Haiti.
Reynold Grand'PierreMinistry of Public Health and Population, Government of Haiti, Port au Prince, Haiti.
David LowranceUS Centers for Disease Control and Prevention, Port au Prince, Haiti.
University of Haiti · HTUniversity of Washington · USCenters for Disease Control and Prevention · USCenters for Disease Control and Prevention · UG

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI EDWIN ROBERTO ORELLANA · 1988 to 2026
$104.9M
NIAID NIH HHS P30 AI027757
6 · The paper itself

Abstract

objectivesIn October 2012, the Haitian Ministry of Health endorsed the "Option B+" strategy to eliminate mother-to-child transmission of HIV and achieve HIV epidemic control. The objective of this paper is to assess and identify risk factors for attrition from the national ART program among Option B+ patients in the 12 months after ART initiation.

designThis retrospective cohort study included patients newly initiating ART from October 2012-August 2013 at 68 ART sites covering 45% of all newly enrolled ART patients in all regions of Haiti.

methodsWith data from electronic medical records, we carried out descriptive analysis of sociodemographic, clinical, and pregnancy-related correlates of ART attrition, and used a modified Poisson regression approach to estimate relative risks in a multivariable model.

resultsThere were 2,166 Option B+ patients who initiated ART, of whom 1,023 were not retained by 12 months (47.2%). One quarter (25.3%) dropped out within 3 months of ART initiation. Protective factors included older age, more advanced HIV disease progression, and any adherence counseling prior to ART initiation, while risk factors included starting ART late in gestation, starting ART within 7 days of HIV testing, and using an atypical ART regimen. DISCUSSION: Our study demonstrates early ART attrition among Option B+ patients and contributes evidence on the characteristics of women who are most at risk of attrition in Haiti. Our findings highlight the importance of targeted strategies to support retention among Option B+ patients.

Indexed as

Antiretroviral Therapy, Highly ActiveFemaleHaitiHIV InfectionsHumansMaleOdds RatioPopulation SurveillancePregnancyRetrospective StudiesRisk FactorsTreatment Outcome

Identifiers

PMID28264045
PMCPMC5338795
OpenAlexW2592259507

What OpenQuestion holds

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LicenceCC0
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.