ArticleBiochimica et biophysica acta. General subjects2017
Effects of statins on the immunoglobulin G glycome.
Article in Biochimica et biophysica acta. General subjects, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Targeting Atherosclerosis: Cholesterol-Lowering Therapies with a New Immunometabolic Dress for an Old Disease.Journal of clinical medicine · 2025Article
- Statin effects on immunoglobulin-G glycomic architecture and the link to cardiovascular disease.Research square · 2025Article
- High-Throughput Glycomic Methods.Chemical reviews · 2022Review
- Distinct Longitudinal Changes in Immunoglobulin G N-Glycosylation Associate with Therapy Response in Chronic Inflammatory Diseases.International journal of molecular sciences · 2022Article
- IgGBiomedicines · 2022Article
- The Rapidly Expanding Nexus of Immunoglobulin G N-Glycomics, Suboptimal Health Status, and Precision Medicine.Experientia supplementum (2012) · 2021Article
- Glycosylation and Cardiovascular Diseases.Advances in experimental medicine and biology · 2021Article
- Global variability of the human IgG glycome.Aging · 2020Article
- Metformin and statin use associate with plasma proteinBMJ open diabetes research & care · 2020Article
- Genetic Variants of the MGAT5 Gene Are Functionally Implicated in the Modulation of T Cells Glycosylation and Plasma IgG Glycome Composition in Ulcerative Colitis.Clinical and translational gastroenterology · 2020Article
- The association between subclass-specific IgG Fc N-glycosylation profiles and hypertension in the Uygur, Kazak, Kirgiz, and Tajik populations.Journal of human hypertension · 2018Article
- The changes of immunoglobulin G N-glycosylation in blood lipids and dyslipidaemia.Journal of translational medicine · 2018Observational
- Reply to 'Trace N-glycans including sulphated species may originate from various plasma glycoproteins and not necessarily IgG'.Nature communications · 2018Article
- Deep molecular phenotypes link complex disorders and physiological insult to CpG methylation.Human molecular genetics · 2018Article
- Unravelling Immunoglobulin G Fc N-Glycosylation: A Dynamic Marker Potentiating Predictive, Preventive and Personalised Medicine.International journal of molecular sciences · 2018Review
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
backgroundStatins are among the most widely prescribed medications worldwide and usually many individuals involved in clinical and population studies are on statin therapy. Immunoglobulin G (IgG) glycosylation has been associated with numerous cardiometabolic risk factors.
methodsThe aim of this study was to investigate the possible association of statin use with N-glycosylation of IgG. The association was analyzed in two large population cohorts (TwinsUK and KORA) using hydrophilic interaction liquid chromatography (HILIC-UPLC) in the TwinsUK cohort and reverse phase liquid chromatography coupled with electrospray mass spectrometry (LC-ESI-MS) in the KORA cohort. Afterwards we investigated the same association for only one statin (rosuvastatin) in a subset of individuals from the randomized double-blind placebo-controlled JUPITER study using LC-ESI-MS for IgG glycome and HILIC-UPLC for total plasma N-glycome.
resultsIn the TwinsUK population, the use of statins was associated with higher levels of core-fucosylated biantennary glycan structure with bisecting N-acetylglucosamine (FA2B) and lower levels of core-fucosylated biantennary digalactosylated monosialylated glycan structure (FA2G2S1). The association between statin use and FA2B was replicated in the KORA cohort. In the JUPITER trial we found no statistically significant differences between the randomly allocated placebo and rosuvastatin groups.
conclusionsIn the TwinsUK and KORA cohorts, statin use was associated with a small increase of pro-inflammatory IgG glycan, although this finding was not confirmed in a subset of participants from the JUPITER trial. GENERAL SIGNIFICANCE: Even if the association between IgG N-glycome and statins exists, it is not large enough to pose a problem for glycomic studies.
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