ArticleBehavioural brain research2017
Depression alters maternal extended amygdala response and functional connectivity during distress signals in attachment relationship.
Article in Behavioural brain research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Structural, functional, and metabolic signatures of postpartum depression: A systematic review.Frontiers in psychiatry · 2022Pooled it
- The neuroscience of social feelings: mechanisms of adaptive social functioning.Neuroscience and biobehavioral reviews · 2021Pooled it
- Neural Substrates of Brand Love: An Activation Likelihood Estimation Meta-Analysis of Functional Neuroimaging Studies.Frontiers in neuroscience · 2020Pooled it
- Postpartum depression-associated localized neural dysfunction: a voxel-wise meta-analysis of amplitude and synchronization alterations in resting-state fMRI.Frontiers in psychiatry · 2025Review
- Maternal cortisol concentration is associated with reduced brain activation to infant cry and more intrusive parenting behavior.Psychoneuroendocrinology · 2025Article
- Hormonal and structural transformations in the caregiver's brain: Examining themes in parental neurobiology.AIMS neuroscience · 2025Review
- Longitudinal changes in attention bias to infant crying in primiparous mothers.Frontiers in behavioral neuroscience · 2023Article
- Trait coping styles and the maternal neural and behavioral sensitivity to an infant.Scientific reports · 2022Article
- Compassion within conflict: Toward a computational theory of social groups informed by maternal brain physiology.The Behavioral and brain sciences · 2022Article
- Recent Neuroscience Advances in Human Parenting.Advances in neurobiology · 2022Article
- A history of previous childbirths is linked to women's white matter brain age in midlife and older age.Human brain mapping · 2021Article
- Reported maternal childhood maltreatment experiences, amygdala activation and functional connectivity to infant cry.Social cognitive and affective neuroscience · 2021Article
- Reduced Child-Oriented Face Mirroring Brain Responses in Mothers With Opioid Use Disorder: An Exploratory Study.Frontiers in psychology · 2021Article
- Mothers' neural response to valenced infant interactions predicts postpartum depression and anxiety.PloS one · 2021Article
- How stress can influence brain adaptations to motherhood.Frontiers in neuroendocrinology · 2021Review
- Neurobiology of peripartum mental illness.Handbook of clinical neurology · 2021Review
- Characterizing the Brain Structural Adaptations Across the Motherhood Transition.Frontiers in global women's health · 2021Review
- Associations between stress exposure and new mothers' brain responses to infant cry sounds.NeuroImage · 2020Article
- Adaptations in reward-related behaviors and mesolimbic dopamine function during motherhood and the postpartum period.Frontiers in neuroendocrinology · 2020Review
- The Application of Connectome-Based Predictive Modeling to the Maternal Brain: Implications for Mother-Infant Bonding.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Maternal attachment-related parenting behaviors require mothers to regulate self-related and child-related distress. Emotion regulation is, in turn, influenced by maternal mood and personal developmental history. In the current study we examined how depressive mood may alter maternal limbic system function and functional connectivity underlying defensive and hedonic motivations. Twenty nine mothers were recruited to undergo a baby-cry task during a functional magnetic resonance imaging (fMRI) scan. Based on self-reported depression symptoms and clinical interview, the participants were grouped as healthy controls (n=15) and currently depressed (n=14). In the baby-cry task, 30s-long auditory stimuli of baby-cry sounds were presented to simulate four conditions: generic baby-cry (Just-Listen), baby-cry as if it were their own child's cry (Your-Baby), baby-cry as if it were themselves (Self), and matched control sounds (Noise). Depressed mothers, as compared to healthy controls, showed greater Self versus Just-Listen responses in left extended amygdala and decreased functional coupling between this left extended amygdala as the seed and nucleus accumbens (NAc) in self-oriented (Self versus Just-Listen) and child-oriented (Your-Baby versus Just-Listen) distress signals. Moreover, the extended amygdala's differential functional connectivity with dorsomedial prefrontal cortex (dmPFC) during the Your-Baby versus Self was increased for depressed mothers and decreased for healthy controls. Thus, depression may affect mothers by increasing baby-cry threat responses and dysregulating associations between threat and heathy child-oriented parenting motivations. These results are discussed in the context of attachment and self-psychology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.