ArticleNature genetics2017
Single-molecule sequencing and chromatin conformation capture enable de novo reference assembly of the domestic goat genome.
Article in Nature genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 388 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
388 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genomic Advancements in Assessing Growth Performance, Meat Quality, and Carcass Characteristics of Goats in Sub-Saharan Africa: A Systematic Review.International journal of molecular sciences · 2025Pooled it
- Integrated Genome-Wide Association Studies and Selection Signature Analysis Reveal the Genetic Architecture of the Wattle Trait in Goats.Animal genetics · 2026Article
- Inference of Genetic Structure and the Process of Population Formation in Nepalese Native Goats Using Uniparental and Genome-Wide Markers.Animals : an open access journal from MDPI · 2026Article
- Genomic Dissection of Growth Traits and Spatial Independence from Breed-Defining Loci in Jining Grey Goats.Animals : an open access journal from MDPI · 2026Article
- A chromosome-level reference genome for the colonial marine hydrozoan Podocoryna americana.G3 (Bethesda, Md.) · 2026Article
- Differential Expression of MicroRNAs in the Mammary Gland of Lactating and Dry Murciano-Granadina Goats.Animals : an open access journal from MDPI · 2026Article
- ASAP1 gene InDel variants are associated with enhanced goat resistance against Brucella infection.Animal bioscience · 2026Article
- Sheep erythrocyte potassium locus highlights MYADM family regulation of electroneutral potassium chloride cotransporters (KCC).BMC genomics · 2026Article
- Identification of a recessiveVeterinary and animal science · 2026Article
- A single-cell transcriptomic atlas identifies key progenitor populations driving postnatal horn bud development in goats (Capra hircus).Communications biology · 2026Article
- Ancient genomes reveal the genetic history of domestic goats on the Qinghai-Xizang Plateau approximately 3 600 years ago.Zoological research · 2026Article
- Evolution and Comparative Analysis of Sheep Reference Genomes: From Fragmented Assemblies to Telomere-to-Telomere Genomics.Biology · 2026Review
- A chromosome-level genome assembly for the colonial marine hydrozoanbioRxiv : the preprint server for biology · 2026Article
- Chromosome-scale genome assembly and annotation of the water monitor lizard, Varanus salvator.Scientific data · 2026Article
- Epigenetic and transcriptional profiling of secondary hair follicle stem cells during cashmere growth.Scientific data · 2026Article
- Progress on genome-wide association studies and selection signature analysis for agronomic traits in Chinese sheep and goats: review.Animal bioscience · 2026Article
- Genome characteristics and identification of reproduction-related genes in Southwest meat goats.BMC genomics · 2026Article
- Article
- Chromosome-scale Genome Assembly of the Most Abundant Ectomycorrhizal Fungus Cenococcum Geophilum Reveals Massive TE Expansion and RIP Defense Mechanism.Genome biology and evolution · 2026Article
- Distribution and shared evolutionary history of the Fumonisin and AAL toxin biosynthetic gene clusters.BMC genomics · 2026Article
328 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
30 authors.
Funding
Abstract
The decrease in sequencing cost and increased sophistication of assembly algorithms for short-read platforms has resulted in a sharp increase in the number of species with genome assemblies. However, these assemblies are highly fragmented, with many gaps, ambiguities, and errors, impeding downstream applications. We demonstrate current state of the art for de novo assembly using the domestic goat (Capra hircus) based on long reads for contig formation, short reads for consensus validation, and scaffolding by optical and chromatin interaction mapping. These combined technologies produced what is, to our knowledge, the most continuous de novo mammalian assembly to date, with chromosome-length scaffolds and only 649 gaps. Our assembly represents a ∼400-fold improvement in continuity due to properly assembled gaps, compared to the previously published C. hircus assembly, and better resolves repetitive structures longer than 1 kb, representing the largest repeat family and immune gene complex yet produced for an individual of a ruminant species.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.