ArticleBlood transfusion = Trasfusione del sangue2017
Iron-deficient erythropoiesis in blood donors and red blood cell recovery after transfusion: initial studies with a mouse model.
Article in Blood transfusion = Trasfusione del sangue, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- Trial
- Latent iron deficiency as a silent driver of donor attrition in high-frequency plateletpheresis donors: a longitudinal cohort study.Annals of hematology · 2026Article
- Dietary iron deficiency impairs effector function of memory T cells following influenza infection.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Reticulocytes in donor blood units enhance red blood cell alloimmunization.Haematologica · 2023Article
- Associations of donor, component, and recipient factors on hemoglobin increments following red blood cell transfusion in very low birth weight infants.Transfusion · 2023Article
- Phytochemical composition and bioactivities ofHeliyon · 2022Article
- Current Understanding of the Relationship between Blood Donor Variability and Blood Component Quality.International journal of molecular sciences · 2021Review
- Long-Term Course of Haemoglobin and Ferritin Values in High-Frequency Donors of Whole Blood and Double Erythrocyte Apheresis.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2021Article
- Spatial variations and determinants of anemia among under-five children in Ethiopia, EDHS 2005-2016.PloS one · 2021Article
- Host serum iron modulates dengue virus acquisition by mosquitoes.Nature microbiology · 2019Article
- Article
- Article
- Donor Iron Deficiency Study (DIDS): protocol of a study to test whether iron deficiency in blood donors affects red blood cell recovery after transfusion.Blood transfusion = Trasfusione del sangue · 2019Article
- Hitchhiker's guide to the red blood cell storage lesion.Blood transfusion = Trasfusione del sangue · 2019Article
- Frequent blood donations alter susceptibility of red blood cells to storage- and stress-induced hemolysis.Transfusion · 2019Article
- Article
- The impact of red cell storage age on transfused patients with sickle cell disease: protocol of a pilot randomized clinical trial to evaluate changes in inflammation and clinical transfusion efficacy.Blood transfusion = Trasfusione del sangueArticle
- The Red Blood Cell-Improving Transfusions for Chronically Transfused Recipients (RBC-IMPACT) study: protocol description of an international multi-site observational clinical study.Blood transfusion = Trasfusione del sangueReview
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundMost frequent red cell (RBC) donors and many first-time donors are iron deficient, but meet haemoglobin standards. However, the effects of donation-induced iron deficiency on RBC storage quality are unknown. Thus, we used a mouse model to determine if donor iron deficiency reduced post-transfusion RBC recovery.
methodsWeanling mice received a control diet or an iron-deficient diet. A third group receiving the iron-deficient diet was also phlebotomised weekly. This provided 3 groups of mice with different iron status: (1) iron replete, (2) mild iron deficiency with iron-deficient erythropoiesis, and (3) iron-deficiency anaemia. At ten weeks of age, blood was collected, leucoreduced, and stored at 4 ºC. After 12 days of storage, 24-hour (h) post-transfusion RBC recovery was quantified in recipients by flow cytometry.
resultsBefore blood collection, mean haemoglobin concentrations in the iron-replete, iron-deficient, and iron-deficiency anaemia donor mice were 16.5±0.4, 11.5±0.4, and 7.0±1.4 [g/dL± 1 standard deviation (SD)], respectively (p<0.01 for all comparisons between groups). The 24-h post-transfusion RBC recoveries in recipients receiving transfusions from these three cohorts were 77.1±13.2, 66.5±10.9, and 46.7±15.9 (% ±1 SD), respectively (p<0.05 for all comparisons between groups). DISCUSSION: In summary, donor iron deficiency significantly reduced 24-h post-transfusion RBC recovery in recipient mice. RBCs from mice with mild iron deficiency and iron-deficient erythropoiesis, with haemoglobin levels similar to those used for human autologous blood donation, had intermediate post-transfusion RBC recovery, as compared to iron-replete donors and those with iron-deficiency anaemia. This suggests that, in addition to the effects of iron deficiency on donor health, frequent blood donation, leading to iron-deficient erythropoiesis, may also have adverse effects for transfusion recipients.
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