ReviewBlood transfusion = Trasfusione del sangue2017
Red blood cell components: time to revisit the sources of variability.
Review in Blood transfusion = Trasfusione del sangue, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Epidemiology of glucose-6-phosphate dehydrogenase deficiency in 10 malaria-endemic countries in sub-Saharan Africa: a systematic review.The Pan African medical journal · 2025Pooled it
- Transfusion of packed red blood cells at the end of shelf life is associated with increased risk of mortality - a pooled patient data analysis of 16 observational trials.Haematologica · 2018Pooled it
- Donor- and unit-specific factors influencing hemolysis in stored canine and feline packed red blood cells.Frontiers in veterinary science · 2026Article
- Article
- Donor age contributes more to the rheological properties of stored red blood cells than donor sex and biological age distribution.Blood advances · 2025Article
- Altered RBC deformability in diabetes: clinical characteristics and RBC pathophysiology.Cardiovascular diabetology · 2024Article
- Need to reconsider national quality standards for red cell components: Evidence from a retrospective observational analysis.The Indian journal of medical research · 2024Observational
- Epidemiology of Glucose-6-Phosphate Dehydrogenase Deficiency in Arab Countries: Insights from a Systematic Review.Journal of clinical medicine · 2023Review
- Article
- Omics Technologies in Veterinary Medicine: Literature Review and Perspectives in Transfusion Medicine.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2023Review
- Syncope Following Treatment of UTI: A Case of Acute Hemolytic Anemia, Methemoglobinemia and Acute Renal Dysfunction Following Phenazopyridine Use in a Patient With G6PD Deficiency.Journal of community hospital internal medicine perspectives · 2023Article
- Recent advances in micro-sized oxygen carriers inspired by red blood cells.Science and technology of advanced materials · 2023Review
- Assessing quality of blood components derived from whole blood treated with riboflavin and ultraviolet light and separated with a fully automated device.Blood transfusion = Trasfusione del sangue · 2022Article
- Sex-related aspects of the red blood cell storage lesion.Blood transfusion = Trasfusione del sangue · 2021Article
- Current Understanding of the Relationship between Blood Donor Variability and Blood Component Quality.International journal of molecular sciences · 2021Review
- Hemolysis Pathways during Storage of Erythrocytes and Inter-Donor Variability in Erythrocyte Morphology.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2021Article
- Deformability of Stored Red Blood Cells.Frontiers in physiology · 2021Review
- The effect of perturbations of the glycocalyx on microvascular perfusion in the obese trauma population: an in vitro study.Trauma surgery & acute care open · 2021Article
- Article
- Heterogeneity of Red Blood Cells: Causes and Consequences.Frontiers in physiology · 2020Review
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Quality and safety of red blood cell (RBC) components is managed by screening of donors and strict regulatory controls of blood collection, processing and storage procedures. Despite these efforts, variations in RBC component quality exist as exemplified by the wide range in storage-induced haemolysis. This article provides a brief overview of the variables that contribute or potentially contribute to the quality of stored RBC components, including blood collection, processing, and donor-related variables. Particular focus is made on donor health and lifestyle factors that are not specifically screened and may impact on the physicobiochemical properties of RBCs and their storability. Inflammatory and oxidative stress states may be especially relevant as RBCs are susceptible to oxidative injury. Few studies have investigated the effect of specific donor-related variables on the quality of stored RBC components. Donor-related variables may be unaccounted confounders in the "age of blood" clinical studies that compared outcomes following transfusion of fresher or longer-stored RBC components. The conclusion is drawn that the blood donor is the greatest source of RBC component variability and the least "regulated" aspect of blood component production. It is proposed that more research is needed to better understand the connection between donor-related variables and quality consistency of stored RBC components. This could be very important given the impact of modern lifestyles that sees escalating rates of non-communicable health conditions that are associated with increased oxidative stress, such as hypertension, obesity and diabetes in children and adults, as well as an ageing population in many countries. The effect of these changes to global health and population demographics will impact on blood donor panels, and without significant new research, the consequences on the quality of stored blood components and transfusion outcomes are unknown.
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