ArticleScientific reports2017
Effects of DBS in parkinsonian patients depend on the structural integrity of frontal cortex.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Coordinate based meta-analysis of motor functional imaging in Parkinson's: disease-specific patterns and modulation by dopamine replacement and deep brain stimulation.Brain imaging and behavior · 2020Pooled it
- Boosting hemianopia recovery: the power of interareal cross-frequency brain stimulation.Brain : a journal of neurology · 2025Trial
- Pretreatment brain volumes can affect the effectiveness of deep brain stimulation in Parkinson's disease patients.Scientific reports · 2020Trial
- Functional Connectivity and Volumetrics Improve Outcome Prediction for Deep Brain Stimulation in Parkinson's Disease.Movement disorders clinical practice · 2025Article
- Preoperative structural networks based on DTI predicts initial subthalamic nucleus stimulation outcome in parkinson's disease.Scientific reports · 2025Article
- Boundary complexity of cortical and subcortical areas predicts deep brain stimulation outcomes in Parkinson's disease.Nature communications · 2025Article
- Microstructure is associated with motor outcomes following Deep Brain Stimulation in Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Neurophysiological gradient in the Parkinsonian subthalamic nucleus as a marker for motor symptoms and apathy.NPJ Parkinson's disease · 2025Article
- Clinical and Brain Morphometry Predictors of Deep Brain Stimulation Outcome in Parkinson's Disease.Brain topography · 2024Article
- Individual Structural Covariance Network Predicts Long-Term Motor Improvement in Parkinson Disease with Subthalamic Nucleus Deep Brain Stimulation.AJNR. American journal of neuroradiology · 2024Article
- New Perspectives of Deep Brain Stimulation Indications for Parkinson's Disease: A Critical Review.Brain sciences · 2024Review
- No evidence for an association of voxel-based morphometry with short-term non-motor outcomes in deep brain stimulation for Parkinson's disease.NPJ Parkinson's disease · 2024Article
- A structural magnetic resonance imaging review of clinical motor outcomes from deep brain stimulation in movement disorders.Brain communications · 2023Review
- A systematic review of brain morphometry related to deep brain stimulation outcome in Parkinson's disease.NPJ Parkinson's disease · 2022Review
- Deciphering the Network Effects of Deep Brain Stimulation in Parkinson's Disease.Neurology and therapy · 2022Article
- Differences in neuroanatomy and functional connectivity between motor subtypes of Parkinson's disease.Frontiers in neuroscience · 2022Article
- Oxidative stress factors in Parkinson's disease.Neural regeneration research · 2021Review
- Neuroimaging evaluation of deep brain stimulation in the treatment of representative neurodegenerative and neuropsychiatric disorders.Bioelectronic medicine · 2021Review
- The rostro-caudal gradient in the prefrontal cortex and its modulation by subthalamic deep brain stimulation in Parkinson's disease.Scientific reports · 2021Article
- Prediction of Deep Brain Stimulation Outcome in Parkinson's Disease With Connectome Based on Hemispheric Asymmetry.Frontiers in neuroscience · 2021Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While deep brain stimulation of the subthalamic nucleus (STN-DBS) has evolved to an evidence-based standard treatment for Parkinson's disease (PD), the targeted cerebral networks are poorly described and no objective predictors for the postoperative clinical response exist. To elucidate the systemic mechanisms of DBS, we analysed cerebral grey matter properties using cortical thickness measurements and addressed the dependence of structural integrity on clinical outcome. Thirty one patients with idiopathic PD without dementia (23 males, age: 63.4 ± 9.3, Hoehn and Yahr: 3.5 ± 0.8) were selected for DBS treatment. The patients underwent whole-brain preoperative T1 MR-Imaging at 3 T. Grey matter integrity was assessed by cortical thickness measurements with FreeSurfer. The clinical motor outcome markedly improved after STN-DBS in comparison to the preoperative condition. The cortical thickness of the frontal lobe (paracentral area and superior frontal region) predicted the clinical improvement after STN-DBS. Moreover, in patients with cortical atrophy of these areas a higher stimulation voltage was needed for an optimal clinical response. Our data suggest that the effects of STN-DBS in PD directly depend on frontal lobe grey matter integrity. Cortical atrophy of this region might represent a distinct predictor of a poor motor outcome after STN-DBS in PD patients.
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