Evidence map›Paper›PMID 28262740›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2017

Effect of Cigarette Smoking on a Marker for Neuroinflammation: A [

Arthur L Brody, Robert Hubert, Ryutaro Enoki, Lizette Y Garcia, Michael S Mamoun, Kyoji Okita, Edythe D London, Erika L Nurmi, Lauren C Seaman, Mark A Mandelkern

Erratum issued Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT01721473 (Nicotinic Acetylcholine Receptor Density and Veteran Cigarette Smokers), which is not on this map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01721473 completednot on this map

Nicotinic Acetylcholine Receptor Density and Veteran Cigarette Smokers

TypeobservationalSponsorVA Office of Research and DevelopmentRan2012 to 2016Enrolled184ConditionsPositron Emission TomographyArmspositron emission tomography scan
3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Cigarette smoking is associated with reduced neuroinflammation and better cognitive control in people living with HIV.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
  6. Observational
  7. Review
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  9. Article
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  11. Article
  12. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Arthur L BrodyDepartment of Psychiatry, University of California at San Diego, San Diego, CA, USA.
Robert HubertDepartment of Research, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA.
Ryutaro EnokiDepartment of Research, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA.
Lizette Y GarciaDepartment of Research, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA.
Michael S MamounDepartment of Research, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA.
Kyoji OkitaDepartment of Research, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA.
Edythe D LondonDepartment of Psychiatry, University of California at Los Angeles, Los Angeles, CA, USA.
Erika L NurmiDepartment of Psychiatry, University of California at Los Angeles, Los Angeles, CA, USA.
Lauren C SeamanDepartment of Psychiatry, University of California at Los Angeles, Los Angeles, CA, USA.
Mark A MandelkernDepartment of Radiology, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA.
VA Greater Los Angeles Healthcare System · USUniversity of California, Los Angeles · USUniversity of California San Diego · US

Funding

UCLA Training Program in Translational Neuroscience of Drug Abuse (TNDA)T32DA024635 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LARA A. RAY, Kate M Wassum · 2008 to 2026
$6.2M
Nicotine Receptor Density & Dopamine System Function in Smokers: Treatment EffectR01DA020872 · NIDA · BRENTWOOD BIOMEDICAL RESEARCH INSTITUTE · PI BRODY, ARTHUR · 2005 to 2013
$2.0M
CSRD VA I01 CX000412NIDA NIH HHS R01 DA020872NIDA NIH HHS T32 DA024635
6 · The paper itself

Abstract

In the brain, microglia continuously scan the surrounding extracellular space in order to respond to damage or infection by becoming activated and participating in neuroinflammation. When activated, microglia increase the expression of translocator protein (TSPO) 18 kDa, thereby making the TSPO expression a marker for neuroinflammation. We used the radiotracer [

Indexed as

AcetamidesAdolescentAdultAgedBiomarkersBrainCase-Control StudiesCigarette SmokingFemaleFunctional NeuroimagingGenotypeHumansInflammationMaleMicrogliaMiddle AgedAcetamidesBiomarkersDAA 1106NicotinePhenyl EthersRadiopharmaceuticalsReceptors, GABATSPO protein, human

Identifiers

PMID28262740
PMCPMC5518907
OpenAlexW2594416440

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.