ArticleScientific reports2017
Visualization of neuritic plaques in Alzheimer's disease by polarization-sensitive optical coherence microscopy.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 50 citations in OpenAlex.
- Discerning Amyloid‑β and Tau Pathologies with Learning-Based Quantum Sensing.ACS photonics · 2025Article
- Morphological and Molecular Profiling of Amyloid-β Species in Alzheimer's Pathogenesis.Molecular neurobiology · 2025Review
- Photothermal optical coherence microscopy for studying lipid architecture in human carotid arteries.Biomedical optics express · 2024Article
- Alzheimer's disease pathophysiology in the Retina.Progress in retinal and eye research · 2024Review
- Skin characterization of diabetes mellitus revealed by polarization-sensitive optical coherence tomography imaging.Journal of biomedical optics · 2024Article
- Single-input polarization-sensitive optical coherence tomography through a catheter.Biomedical optics express · 2023Article
- Electrophysiological damage to neuronal membrane alters ephaptic entrainment.Scientific reports · 2023Article
- High-throughput screening for amyloid-Acta pharmaceutica Sinica. B · 2022Article
- Distribution and inter-regional relationship of amyloid-beta plaque deposition in a 5xFAD mouse model of Alzheimer's disease.Frontiers in aging neuroscience · 2022Article
- Influence of the anatomical features of different brain regions on the spatial localization of fiber photometry signals.Biomedical optics express · 2021Article
- Protective Effects of Polydatin Against Dementia-Related Disorders.Current neuropharmacology · 2021Review
- The Progress of Label-Free Optical Imaging in Alzheimer's Disease Screening and Diagnosis.Frontiers in aging neuroscience · 2021Review
- Extracellular Amyloid Deposits in Alzheimer's and Creutzfeldt-Jakob Disease: Similar Behavior of Different Proteins?International journal of molecular sciences · 2020Review
- Evaluating β-amyloidosis progression in Alzheimer's disease with Mueller polarimetry.Biomedical optics express · 2020Article
- Improved Diagnostic Imaging of Brain Tumors by Multimodal Microscopy and Deep Learning.Cancers · 2020Article
- Article
- Additive-color multi-harmonic generation microscopy for simultaneous label-free differentiation of plaques, tangles, and neuronal axons.Biomedical optics express · 2020Article
- High-resolution 3D tractography of fibrous tissue based on polarization-sensitive optical coherence tomography.Experimental biology and medicine (Maywood, N.J.) · 2020Review
- Vectorial birefringence imaging by optical coherence microscopy for assessing fibrillar microstructures in the cornea and limbus.Biomedical optics express · 2020Article
- Retinal analysis of a mouse model of Alzheimer's disease with multicontrast optical coherence tomography.Neurophotonics · 2020Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One major hallmark of Alzheimer's disease (AD) and cerebral amyloid angiopathy (CAA) is the deposition of extracellular senile plaques and vessel wall deposits composed of amyloid-beta (Aβ). In AD, degeneration of neurons is preceded by the formation of Aβ plaques, which show different morphological forms. Most of them are birefringent owing to the parallel arrangement of amyloid fibrils. Here, we present polarization sensitive optical coherence microscopy (PS-OCM) for imaging mature neuritic Aβ plaques based on their birefringent properties. Formalin-fixed, post-mortem brain samples of advanced stage AD patients were investigated. In several cortical brain regions, neuritic Aβ plaques were successfully visualized in tomographic and three-dimensional (3D) images. Cortical grey matter appeared polarization preserving, whereas neuritic plaques caused increased phase retardation. Consistent with the results from PS-OCM imaging, the 3D structure of senile Aβ plaques was computationally modelled for different illumination settings and plaque sizes. Furthermore, the birefringent properties of cortical and meningeal vessel walls in CAA were investigated in selected samples. Significantly increased birefringence was found in smaller vessels. Overall, these results provide evidence that PS-OCM is able to assess amyloidosis based on intrinsic birefringent properties.
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