ArticleNature communications2017
Liquid-state carbon-13 hyperpolarization generated in an MRI system for fast imaging.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed.
- Ultra-low fieldCommunications chemistry · 2026Article
- Preclinical Applications of Magnetic Resonance Imaging in Oncology.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026Review
- Upscaling the Hyperpolarization Sample Volume of an Automated Hydrogenative Parahydrogen-Induced Polarizer.ACS measurement science au · 2025Article
- Indirect Zero-Field Nuclear Magnetic Resonance Spectroscopy.Analytical chemistry · 2025Article
- Overcoming the Challenges of Hyperpolarizing Substrates with Parahydrogen-Induced Polarization in an MRI System.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Homogeneous Catalysts for Hydrogenative PHIP Used in Biomedical Applications.Analysis & sensing · 2025Article
- Rapid in situ carbon-13 hyperpolarization and imaging of acetate and pyruvate esters without external polarizer.Communications chemistry · 2024Article
- Live magnetic observation of parahydrogen hyperpolarization dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- MATRESHCA: Microtesla Apparatus for Transfer of Resonance Enhancement of Spin Hyperpolarization via Chemical Exchange and Addition.Analytical chemistry · 2024Article
- Carbon-13 Radiofrequency Amplification by Stimulated Emission of Radiation of the Hyperpolarized Ketone and Hemiketal Forms of Allyl [1-ACS sensors · 2024Article
- Spying on parahydrogen-induced polarization transfer using a half-tesla benchtop MRI and hyperpolarized imaging enabled by automation.Nature communications · 2023Article
- Article
- Metabolic Tumor Imaging with Rapidly Signal-Enhanced 1-Chemphyschem : a European journal of chemical physics and physical chemistry · 2023Article
- Parahydrogen-induced polarization and spin order transfer in ethyl pyruvate at high magnetic fields.Scientific reports · 2022Article
- RapidAnalytical chemistry · 2022Article
- Synthesis ofChemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Quasi-continuous production of highly hyperpolarized carbon-13 contrast agents every 15 seconds within an MRI system.Communications chemistry · 2022Article
- Frequency-Selective Manipulations of Spins allow Effective and Robust Transfer of Spin Order from Parahydrogen to Heteronuclei in Weakly-Coupled Spin Systems.Chemphyschem : a European journal of chemical physics and physical chemistry · 2022Article
- Hyperpolarization ofRSC advances · 2022Article
- Instrumentation for Hydrogenative Parahydrogen-Based Hyperpolarization Techniques.Analytical chemistry · 2022Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyperpolarized (HP) tracers dramatically increase the sensitivity of magnetic resonance imaging (MRI) to monitor metabolism non-invasively and in vivo. Their production, however, requires an extra polarizing device (polarizer) whose complexity, operation and cost can exceed that of an MRI system itself. Furthermore, the lifetime of HP tracers is short and some of the enhancement is lost during transfer to the application site. Here, we present the production of HP tracers in water without an external polarizer: by Synthesis Amid the Magnet Bore, A Dramatically Enhanced Nuclear Alignment (SAMBADENA) is achieved within seconds, corresponding to a hyperpolarization of ∼20%. As transfer of the tracer is no longer required, SAMBADENA may permit a higher polarization at the time of detection at a fraction of the cost and complexity of external polarizers. This development is particularly promising in light of the recently extended portfolio of biomedically relevant para-hydrogen-tracers and may lead to new diagnostic applications.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.