ArticleNature communications2017
Regulation of phagocyte triglyceride by a STAT-ATG2 pathway controls mycobacterial infection.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 58 citations in OpenAlex.
- The study of immunological markers in tuberculosis across animal models and its translation to human research.Lab animal · 2026Review
- Integrative genomics sheds light on the immunogenetics of tuberculosis in cattle.Communications biology · 2025Article
- Chronic bacterial infections exert metabolic costs in Drosophila melanogaster.The Journal of experimental biology · 2025Article
- Remote disruption of intestinal homeostasis by Mycobacterium abscessus is detrimental to Drosophila survival.Scientific reports · 2024Article
- Microbial metabolism disrupts cytokine activity to impact host immune response.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- DNA damage signaling ineLife · 2024Article
- Hemocyte Nuclei Isolation from Adult Drosophila melanogaster for snRNA-seq.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Atg2 Regulates Cellular and Humoral Immunity inInsects · 2023Article
- Regulating metabolism to shape immune function: Lessons from Drosophila.Seminars in cell & developmental biology · 2023Review
- Galleria mellonella-intracellular bacteria pathogen infection models: the ins and outs.FEMS microbiology reviews · 2023Review
- Mycobacterium abscessus resists the innate cellular response by surviving cell lysis of infected phagocytes.PLoS pathogens · 2023Article
- The reproductive status determines tolerance and resistance toEvolution, medicine, and public health · 2023Article
- Mycobacterium abscessus pathogenesis identified by phenogenomic analyses.Nature microbiology · 2022Article
- Metabolic strategy of macrophages under homeostasis or immune stress inMarine life science & technology · 2022Review
- Triglyceride breakdown from lipid droplets regulates the inflammatory response in macrophages.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Inhibition of Granuloma Triglyceride Synthesis Imparts Control ofFrontiers in immunology · 2021Article
- Autophagy and Host Defense in Nontuberculous Mycobacterial Infection.Frontiers in immunology · 2021Review
- Polarization of Macrophages in Insects: Opening Gates for Immuno-Metabolic Research.Frontiers in cell and developmental biology · 2021Review
- Innate immune signaling in Drosophila shifts anabolic lipid metabolism from triglyceride storage to phospholipid synthesis to support immune function.PLoS genetics · 2020Article
- Article
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
Abstract
Mycobacterium tuberculosis remains a global threat to human health, yet the molecular mechanisms regulating immunity remain poorly understood. Cytokines can promote or inhibit mycobacterial survival inside macrophages and the underlying mechanisms represent potential targets for host-directed therapies. Here we show that cytokine-STAT signalling promotes mycobacterial survival within macrophages by deregulating lipid droplets via ATG2 repression. In Drosophila infected with Mycobacterium marinum, mycobacterium-induced STAT activity triggered by unpaired-family cytokines reduces Atg2 expression, permitting deregulation of lipid droplets. Increased Atg2 expression or reduced macrophage triglyceride biosynthesis, normalizes lipid deposition in infected phagocytes and reduces numbers of viable intracellular mycobacteria. In human macrophages, addition of IL-6 promotes mycobacterial survival and BCG-induced lipid accumulation by a similar, but probably not identical, mechanism. Our results reveal Atg2 regulation as a mechanism by which cytokines can control lipid droplet homeostasis and consequently resistance to mycobacterial infection in Drosophila.
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Registered trials
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